Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam

Antimicrobial resistance in Gram-negative bacteria, particularly Enterobacteriaceae, has become a leading cause of morbidity and mortality and a serious public health concern. Gram-negative bacteria carrying extended-spectrum beta-lactamase (ESBL) enzymes now represent a significant proportion of al...

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Autores principales: Schimmenti, A., Brunetti, E., Seminari, E., Mariani, B., Cambieri, P., Orsolini, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112089/
https://www.ncbi.nlm.nih.gov/pubmed/30186645
http://dx.doi.org/10.1155/2018/1854805
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author Schimmenti, A.
Brunetti, E.
Seminari, E.
Mariani, B.
Cambieri, P.
Orsolini, P.
author_facet Schimmenti, A.
Brunetti, E.
Seminari, E.
Mariani, B.
Cambieri, P.
Orsolini, P.
author_sort Schimmenti, A.
collection PubMed
description Antimicrobial resistance in Gram-negative bacteria, particularly Enterobacteriaceae, has become a leading cause of morbidity and mortality and a serious public health concern. Gram-negative bacteria carrying extended-spectrum beta-lactamase (ESBL) enzymes now represent a significant proportion of all bacteria isolated from different countries worldwide. Furthermore, the increasing number of isolates carrying carbapenemases in recent years includes multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) bacteria. Here, we describe what, to our knowledge, is the first case of a patient with a prosthetic joint infection from carbapenemase-resistant Klebsiella pneumoniae (CRKP) successfully treated with ceftazidime-avibactam in Italy.
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spelling pubmed-61120892018-09-05 Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam Schimmenti, A. Brunetti, E. Seminari, E. Mariani, B. Cambieri, P. Orsolini, P. Case Rep Infect Dis Case Report Antimicrobial resistance in Gram-negative bacteria, particularly Enterobacteriaceae, has become a leading cause of morbidity and mortality and a serious public health concern. Gram-negative bacteria carrying extended-spectrum beta-lactamase (ESBL) enzymes now represent a significant proportion of all bacteria isolated from different countries worldwide. Furthermore, the increasing number of isolates carrying carbapenemases in recent years includes multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) bacteria. Here, we describe what, to our knowledge, is the first case of a patient with a prosthetic joint infection from carbapenemase-resistant Klebsiella pneumoniae (CRKP) successfully treated with ceftazidime-avibactam in Italy. Hindawi 2018-08-14 /pmc/articles/PMC6112089/ /pubmed/30186645 http://dx.doi.org/10.1155/2018/1854805 Text en Copyright © 2018 A. Schimmenti et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Schimmenti, A.
Brunetti, E.
Seminari, E.
Mariani, B.
Cambieri, P.
Orsolini, P.
Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_full Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_fullStr Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_full_unstemmed Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_short Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_sort prosthetic joint infection from carbapenemase-resistant klebsiella pneumoniae successfully treated with ceftazidime-avibactam
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112089/
https://www.ncbi.nlm.nih.gov/pubmed/30186645
http://dx.doi.org/10.1155/2018/1854805
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