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Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090

BACKGROUND: Tubercidin (TBN), an adenosine analog with potent antimycobacteria and antitumor bioactivities, highlights an intriguing structure, in which a 7-deazapurine core is linked to the ribose moiety by an N-glycosidic bond. However, the molecular logic underlying the biosynthesis of this antib...

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Detalles Bibliográficos
Autores principales:	Liu, Yan, Gong, Rong, Liu, Xiaoqin, Zhang, Peichao, Zhang, Qi, Cai, You-Sheng, Deng, Zixin, Winkler, Margit, Wu, Jianguo, Chen, Wenqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112128/ https://www.ncbi.nlm.nih.gov/pubmed/30153835 http://dx.doi.org/10.1186/s12934-018-0978-8

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