Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies

BACKGROUND: A central challenge in toxicity testing is the large number of chemicals in commerce that lack toxicological assessment. In response, the Tox21 program is re-focusing toxicity testing from animal studies to less expensive and higher throughput in vitro methods using target/pathway-specif...

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Detalles Bibliográficos
Autores principales: Xia, Menghang, Huang, Ruili, Shi, Qiang, Boyd, Windy A., Zhao, Jinghua, Sun, Nuo, Rice, Julie R., Dunlap, Paul E., Hackstadt, Amber J., Bridge, Matt F., Smith, Marjolein V., Dai, Sheng, Zheng, Wei, Chu, Pei-Hsuan, Gerhold, David, Witt, Kristine L., DeVito, Michael, Freedman, Jonathan H., Austin, Christopher P., Houck, Keith A., Thomas, Russell S., Paules, Richard S., Tice, Raymond R., Simeonov, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112376/
https://www.ncbi.nlm.nih.gov/pubmed/30059008
http://dx.doi.org/10.1289/EHP2589

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