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The association between 25(OH)D levels, frailty status and obesity indices in older adults
BACKGROUND: Vitamin D deficiency is common in older adults and has been linked with frailty and obesity, but it remains to be studied whether frail obese older adults are at higher risk of vitamin D deficiency. Therefore, the aim of this study is to explore the association between frailty, obesity i...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112621/ https://www.ncbi.nlm.nih.gov/pubmed/30153256 http://dx.doi.org/10.1371/journal.pone.0198650 |
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author | Sousa-Santos, Ana Rita Afonso, Cláudia Santos, Alejandro Borges, Nuno Moreira, Pedro Padrão, Patrícia Fonseca, Isabel Amaral, Teresa F. |
author_facet | Sousa-Santos, Ana Rita Afonso, Cláudia Santos, Alejandro Borges, Nuno Moreira, Pedro Padrão, Patrícia Fonseca, Isabel Amaral, Teresa F. |
author_sort | Sousa-Santos, Ana Rita |
collection | PubMed |
description | BACKGROUND: Vitamin D deficiency is common in older adults and has been linked with frailty and obesity, but it remains to be studied whether frail obese older adults are at higher risk of vitamin D deficiency. Therefore, the aim of this study is to explore the association between frailty, obesity indices and serum 25(OH)D concentrations. METHODS: 1447 individuals with 65 years or older, participating in a cross-sectional study (Nutrition UP 65) were included. Frailty, according to Fried et al., body mass index (BMI), waist circumference (WC), body roundness index (BRI) and body shape index (ABSI) were evaluated. A stepwise multinomial logistic regression was carried out to quantify the association between 25(OH)D quartiles and independent variables. RESULTS: Median 25(OH)D levels were lower in individuals presenting both frailty and obesity (p<0.001). In the multivariate analysis, pre-frailty (OR: 2.65; 95% CI: 1.63–4.33) and frailty (OR: 3.77; 95% CI: 2.08–6.83) were associated with increased odds of lower 25(OH)D serum levels (first quartile). Regarding obesity indices, the highest categories of BMI (OR: 1.74; 95% CI: 1.06–2.86), WC (OR: 3.46; 95% CI: 1.95–6.15), BRI (OR: 4.35; 95% CI: 2.60–7.29) and ABSI (OR: 3.17 95% CI: 1.86–5.38) were directly associated with lower 25(OH)D serum levels (first quartile). CONCLUSIONS: A positive association between frailty or obesity and lower vitamin D levels was found. Moreover, besides BMI and WC, other indicators of body adiposity, such as BRI and ABSI, were associated with lower 25(OH)D serum concentrations. |
format | Online Article Text |
id | pubmed-6112621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-61126212018-09-17 The association between 25(OH)D levels, frailty status and obesity indices in older adults Sousa-Santos, Ana Rita Afonso, Cláudia Santos, Alejandro Borges, Nuno Moreira, Pedro Padrão, Patrícia Fonseca, Isabel Amaral, Teresa F. PLoS One Research Article BACKGROUND: Vitamin D deficiency is common in older adults and has been linked with frailty and obesity, but it remains to be studied whether frail obese older adults are at higher risk of vitamin D deficiency. Therefore, the aim of this study is to explore the association between frailty, obesity indices and serum 25(OH)D concentrations. METHODS: 1447 individuals with 65 years or older, participating in a cross-sectional study (Nutrition UP 65) were included. Frailty, according to Fried et al., body mass index (BMI), waist circumference (WC), body roundness index (BRI) and body shape index (ABSI) were evaluated. A stepwise multinomial logistic regression was carried out to quantify the association between 25(OH)D quartiles and independent variables. RESULTS: Median 25(OH)D levels were lower in individuals presenting both frailty and obesity (p<0.001). In the multivariate analysis, pre-frailty (OR: 2.65; 95% CI: 1.63–4.33) and frailty (OR: 3.77; 95% CI: 2.08–6.83) were associated with increased odds of lower 25(OH)D serum levels (first quartile). Regarding obesity indices, the highest categories of BMI (OR: 1.74; 95% CI: 1.06–2.86), WC (OR: 3.46; 95% CI: 1.95–6.15), BRI (OR: 4.35; 95% CI: 2.60–7.29) and ABSI (OR: 3.17 95% CI: 1.86–5.38) were directly associated with lower 25(OH)D serum levels (first quartile). CONCLUSIONS: A positive association between frailty or obesity and lower vitamin D levels was found. Moreover, besides BMI and WC, other indicators of body adiposity, such as BRI and ABSI, were associated with lower 25(OH)D serum concentrations. Public Library of Science 2018-08-28 /pmc/articles/PMC6112621/ /pubmed/30153256 http://dx.doi.org/10.1371/journal.pone.0198650 Text en © 2018 Sousa-Santos et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sousa-Santos, Ana Rita Afonso, Cláudia Santos, Alejandro Borges, Nuno Moreira, Pedro Padrão, Patrícia Fonseca, Isabel Amaral, Teresa F. The association between 25(OH)D levels, frailty status and obesity indices in older adults |
title | The association between 25(OH)D levels, frailty status and obesity indices in older adults |
title_full | The association between 25(OH)D levels, frailty status and obesity indices in older adults |
title_fullStr | The association between 25(OH)D levels, frailty status and obesity indices in older adults |
title_full_unstemmed | The association between 25(OH)D levels, frailty status and obesity indices in older adults |
title_short | The association between 25(OH)D levels, frailty status and obesity indices in older adults |
title_sort | association between 25(oh)d levels, frailty status and obesity indices in older adults |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112621/ https://www.ncbi.nlm.nih.gov/pubmed/30153256 http://dx.doi.org/10.1371/journal.pone.0198650 |
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