ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts

BACKGROUND: Temozolomide (TMZ) is active against glioblastomas (GBM) in which the O6-methylguanine-DNA methyltransferase (MGMT) gene is silenced. However, even in responsive cases, its beneficial effect is undermined by the emergence of drug resistance. Here, we tested whether inhibition of poly (AD...

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Detalles Bibliográficos
Autores principales: Yuan, Alice L., Ricks, Christian B., Bohm, Alexandra K., Lun, Xueqing, Maxwell, Lori, Safdar, Shahana, Bukhari, Shazreh, Gerber, Amanda, Sayeed, Wajid, Bering, Elizabeth. A., Pedersen, Haley, Chan, Jennifer A., Shen, Yaoqing, Marra, Marco, Kaplan, David R., Mason, Warren, Goodman, Lindsey D., Ezhilarasan, Ravesanker, Kaufmann, Ascher B., Cabral, Matthew, Robbins, Steve M., Senger, Donna L., Cahill, Daniel P., Sulman, Erik P., Cairncross, J. Gregory, Blough, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112648/
https://www.ncbi.nlm.nih.gov/pubmed/30153289
http://dx.doi.org/10.1371/journal.pone.0202860

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