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Effects of perinatal blood pressure on maternal brain functional connectivity

Perinatal hypertensive disorder including pre-eclampsia is a systemic syndrome that occurs in 3–5% of pregnant women. It can result in various degrees of brain damage. A recent study suggested that even gestational hypertension without proteinuria can cause cardiovascular or cognitive impairments la...

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Autores principales: Kurosaki, Hiromichi, Nakahata, Katsutoshi, Donishi, Tomohiro, Shiro, Michihisa, Ino, Kazuhiko, Terada, Masaki, Kawamata, Tomoyuki, Kaneoke, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112678/
https://www.ncbi.nlm.nih.gov/pubmed/30153298
http://dx.doi.org/10.1371/journal.pone.0203067
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author Kurosaki, Hiromichi
Nakahata, Katsutoshi
Donishi, Tomohiro
Shiro, Michihisa
Ino, Kazuhiko
Terada, Masaki
Kawamata, Tomoyuki
Kaneoke, Yoshiki
author_facet Kurosaki, Hiromichi
Nakahata, Katsutoshi
Donishi, Tomohiro
Shiro, Michihisa
Ino, Kazuhiko
Terada, Masaki
Kawamata, Tomoyuki
Kaneoke, Yoshiki
author_sort Kurosaki, Hiromichi
collection PubMed
description Perinatal hypertensive disorder including pre-eclampsia is a systemic syndrome that occurs in 3–5% of pregnant women. It can result in various degrees of brain damage. A recent study suggested that even gestational hypertension without proteinuria can cause cardiovascular or cognitive impairments later in life. We hypothesized that perinatal hypertension affects the brain functional connectivity (FC) regardless of the clinical manifestation of brain functional impairment. In the present study, we analyzed regional global connectivity (rGC) strength (mean cross-correlation coefficient between a brain region and all other regions) using resting-state functional magnetic resonance imaging to clarify brain FC changes associated with perinatal blood pressure using data from 16 women with a normal pregnancy and 21 pregnant women with pre-eclampsia. The rGC values in the bilateral orbitofrontal gyri were negatively correlated with diastolic blood pressure (dBP), which could not be explained by other pre-eclampsia symptoms. The strength of FC seeding at the left orbitofrontal gyrus was negatively correlated with dBP in the anterior cingulate gyri and right middle frontal gyrus. These results suggest that dBP elevation during pregnancy can affect the brain FC. Since FC is known to be associated with various brain functions and diseases, our findings are important for elucidating the neural correlate of cognitive impairments related to hypertension in pregnancy.
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spelling pubmed-61126782018-09-17 Effects of perinatal blood pressure on maternal brain functional connectivity Kurosaki, Hiromichi Nakahata, Katsutoshi Donishi, Tomohiro Shiro, Michihisa Ino, Kazuhiko Terada, Masaki Kawamata, Tomoyuki Kaneoke, Yoshiki PLoS One Research Article Perinatal hypertensive disorder including pre-eclampsia is a systemic syndrome that occurs in 3–5% of pregnant women. It can result in various degrees of brain damage. A recent study suggested that even gestational hypertension without proteinuria can cause cardiovascular or cognitive impairments later in life. We hypothesized that perinatal hypertension affects the brain functional connectivity (FC) regardless of the clinical manifestation of brain functional impairment. In the present study, we analyzed regional global connectivity (rGC) strength (mean cross-correlation coefficient between a brain region and all other regions) using resting-state functional magnetic resonance imaging to clarify brain FC changes associated with perinatal blood pressure using data from 16 women with a normal pregnancy and 21 pregnant women with pre-eclampsia. The rGC values in the bilateral orbitofrontal gyri were negatively correlated with diastolic blood pressure (dBP), which could not be explained by other pre-eclampsia symptoms. The strength of FC seeding at the left orbitofrontal gyrus was negatively correlated with dBP in the anterior cingulate gyri and right middle frontal gyrus. These results suggest that dBP elevation during pregnancy can affect the brain FC. Since FC is known to be associated with various brain functions and diseases, our findings are important for elucidating the neural correlate of cognitive impairments related to hypertension in pregnancy. Public Library of Science 2018-08-28 /pmc/articles/PMC6112678/ /pubmed/30153298 http://dx.doi.org/10.1371/journal.pone.0203067 Text en © 2018 Kurosaki et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kurosaki, Hiromichi
Nakahata, Katsutoshi
Donishi, Tomohiro
Shiro, Michihisa
Ino, Kazuhiko
Terada, Masaki
Kawamata, Tomoyuki
Kaneoke, Yoshiki
Effects of perinatal blood pressure on maternal brain functional connectivity
title Effects of perinatal blood pressure on maternal brain functional connectivity
title_full Effects of perinatal blood pressure on maternal brain functional connectivity
title_fullStr Effects of perinatal blood pressure on maternal brain functional connectivity
title_full_unstemmed Effects of perinatal blood pressure on maternal brain functional connectivity
title_short Effects of perinatal blood pressure on maternal brain functional connectivity
title_sort effects of perinatal blood pressure on maternal brain functional connectivity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112678/
https://www.ncbi.nlm.nih.gov/pubmed/30153298
http://dx.doi.org/10.1371/journal.pone.0203067
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