Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeutics

Endoplasmic reticulum (ER) stress can be activated by various pathological and physiological conditions including the unfolded protein response (UPR) to restore homeostasis. The UPR signaling pathways initiated by double-stranded RNA-activated protein kinase (PKR) like ER kinase (PERK), inositol req...

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Detalles Bibliográficos
Autores principales: Asha, Kumari, Sharma-Walia, Neelam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112759/
https://www.ncbi.nlm.nih.gov/pubmed/30159133
http://dx.doi.org/10.18632/oncotarget.25886
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author Asha, Kumari
Sharma-Walia, Neelam
author_facet Asha, Kumari
Sharma-Walia, Neelam
author_sort Asha, Kumari
collection PubMed
description Endoplasmic reticulum (ER) stress can be activated by various pathological and physiological conditions including the unfolded protein response (UPR) to restore homeostasis. The UPR signaling pathways initiated by double-stranded RNA-activated protein kinase (PKR) like ER kinase (PERK), inositol requiring enzyme 1 α (IRE1α), and activating transcription factor 6 (ATF6) are vital for tumor growth, aggressiveness, microenvironment remodeling, and resistance to cancer therapeutics. This review focuses on the role of ER stress and activity of UPR signaling pathways involved in tumor formation and uncontrolled cell proliferation during various cancers and viral malignancies.
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spelling pubmed-61127592018-08-29 Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeutics Asha, Kumari Sharma-Walia, Neelam Oncotarget Review Endoplasmic reticulum (ER) stress can be activated by various pathological and physiological conditions including the unfolded protein response (UPR) to restore homeostasis. The UPR signaling pathways initiated by double-stranded RNA-activated protein kinase (PKR) like ER kinase (PERK), inositol requiring enzyme 1 α (IRE1α), and activating transcription factor 6 (ATF6) are vital for tumor growth, aggressiveness, microenvironment remodeling, and resistance to cancer therapeutics. This review focuses on the role of ER stress and activity of UPR signaling pathways involved in tumor formation and uncontrolled cell proliferation during various cancers and viral malignancies. Impact Journals LLC 2018-08-07 /pmc/articles/PMC6112759/ /pubmed/30159133 http://dx.doi.org/10.18632/oncotarget.25886 Text en Copyright: © 2018 Asha et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Asha, Kumari
Sharma-Walia, Neelam
Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeutics
title Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeutics
title_full Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeutics
title_fullStr Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeutics
title_full_unstemmed Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeutics
title_short Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeutics
title_sort virus and tumor microenvironment induced er stress and unfolded protein response: from complexity to therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112759/
https://www.ncbi.nlm.nih.gov/pubmed/30159133
http://dx.doi.org/10.18632/oncotarget.25886
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