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Obesity, obstructive sleep apnea and type 2 diabetes mellitus: Epidemiology and pathophysiologic insights
Obesity is a major global health issue, and its prevalence is increasing. Obesity is associated with much comorbidity such as obstructive sleep apnea (OSA), type 2 diabetes mellitus (T2DM), and cardiovascular diseases (CVD). Obesity is also one of the major causative factors of OSA, and OSA itself c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112821/ https://www.ncbi.nlm.nih.gov/pubmed/30167574 |
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author | Jehan, Shazia Myers, Alyson K Zizi, Ferdinand Pandi-Perumal, Seithikurippu R Jean-Louis, Girardin McFarlane, Samy I |
author_facet | Jehan, Shazia Myers, Alyson K Zizi, Ferdinand Pandi-Perumal, Seithikurippu R Jean-Louis, Girardin McFarlane, Samy I |
author_sort | Jehan, Shazia |
collection | PubMed |
description | Obesity is a major global health issue, and its prevalence is increasing. Obesity is associated with much comorbidity such as obstructive sleep apnea (OSA), type 2 diabetes mellitus (T2DM), and cardiovascular diseases (CVD). Obesity is also one of the major causative factors of OSA, and OSA itself can promote the onset of after T2DM because hypoxic episodes decrease insulin sensitivity, and activation of the sympathetic pathway leads to the release of inflammatory markers associated with insulin resistance. Continuous Positive Airway Pressure (CPAP) can be used to ameliorate both conditions, as CPAP decreased hypoxia episodes and increases insulin sensitivity and improves glucose metabolism. Weight-loss strategies play an important role in improving OSA, T2DM, and other associated comorbidities. Lifestyle modification of diet and exercise, medications or bariatric surgery should be considered weight loss. The purpose of this review is to describe the relationship between obesity, OSA, and T2DM. |
format | Online Article Text |
id | pubmed-6112821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
record_format | MEDLINE/PubMed |
spelling | pubmed-61128212018-08-28 Obesity, obstructive sleep apnea and type 2 diabetes mellitus: Epidemiology and pathophysiologic insights Jehan, Shazia Myers, Alyson K Zizi, Ferdinand Pandi-Perumal, Seithikurippu R Jean-Louis, Girardin McFarlane, Samy I Sleep Med Disord Article Obesity is a major global health issue, and its prevalence is increasing. Obesity is associated with much comorbidity such as obstructive sleep apnea (OSA), type 2 diabetes mellitus (T2DM), and cardiovascular diseases (CVD). Obesity is also one of the major causative factors of OSA, and OSA itself can promote the onset of after T2DM because hypoxic episodes decrease insulin sensitivity, and activation of the sympathetic pathway leads to the release of inflammatory markers associated with insulin resistance. Continuous Positive Airway Pressure (CPAP) can be used to ameliorate both conditions, as CPAP decreased hypoxia episodes and increases insulin sensitivity and improves glucose metabolism. Weight-loss strategies play an important role in improving OSA, T2DM, and other associated comorbidities. Lifestyle modification of diet and exercise, medications or bariatric surgery should be considered weight loss. The purpose of this review is to describe the relationship between obesity, OSA, and T2DM. 2018-06-21 2018 /pmc/articles/PMC6112821/ /pubmed/30167574 Text en This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Article Jehan, Shazia Myers, Alyson K Zizi, Ferdinand Pandi-Perumal, Seithikurippu R Jean-Louis, Girardin McFarlane, Samy I Obesity, obstructive sleep apnea and type 2 diabetes mellitus: Epidemiology and pathophysiologic insights |
title | Obesity, obstructive sleep apnea and type 2 diabetes mellitus: Epidemiology and pathophysiologic insights |
title_full | Obesity, obstructive sleep apnea and type 2 diabetes mellitus: Epidemiology and pathophysiologic insights |
title_fullStr | Obesity, obstructive sleep apnea and type 2 diabetes mellitus: Epidemiology and pathophysiologic insights |
title_full_unstemmed | Obesity, obstructive sleep apnea and type 2 diabetes mellitus: Epidemiology and pathophysiologic insights |
title_short | Obesity, obstructive sleep apnea and type 2 diabetes mellitus: Epidemiology and pathophysiologic insights |
title_sort | obesity, obstructive sleep apnea and type 2 diabetes mellitus: epidemiology and pathophysiologic insights |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112821/ https://www.ncbi.nlm.nih.gov/pubmed/30167574 |
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