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Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell

Developing selective inhibitors for proteolytic enzymes that share high sequence homology and structural similarity is important for achieving high target affinity and functional specificity. Here, we used a combination of yeast surface display and dual-color selective library screening to obtain se...

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Detalles Bibliográficos
Autores principales:	Arkadash, Valeria, Radisky, Evette S., Papo, Niv
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112833/ https://www.ncbi.nlm.nih.gov/pubmed/30174795 http://dx.doi.org/10.18632/oncotarget.25885

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