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Conservation of preparatory neural events in monkey motor cortex regardless of how movement is initiated

A time-consuming preparatory stage is hypothesized to precede voluntary movement. A putative neural substrate of motor preparation occurs when a delay separates instruction and execution cues. When readiness is sustained during the delay, sustained neural activity is observed in motor and premotor a...

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Autores principales: Lara, Antonio H, Elsayed, Gamaleldin F, Zimnik, Andrew J, Cunningham, John P, Churchland, Mark M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112854/
https://www.ncbi.nlm.nih.gov/pubmed/30132759
http://dx.doi.org/10.7554/eLife.31826
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author Lara, Antonio H
Elsayed, Gamaleldin F
Zimnik, Andrew J
Cunningham, John P
Churchland, Mark M
author_facet Lara, Antonio H
Elsayed, Gamaleldin F
Zimnik, Andrew J
Cunningham, John P
Churchland, Mark M
author_sort Lara, Antonio H
collection PubMed
description A time-consuming preparatory stage is hypothesized to precede voluntary movement. A putative neural substrate of motor preparation occurs when a delay separates instruction and execution cues. When readiness is sustained during the delay, sustained neural activity is observed in motor and premotor areas. Yet whether delay-period activity reflects an essential preparatory stage is controversial. In particular, it has remained ambiguous whether delay-period-like activity appears before non-delayed movements. To overcome that ambiguity, we leveraged a recently developed analysis method that parses population responses into putatively preparatory and movement-related components. We examined cortical responses when reaches were initiated after an imposed delay, at a self-chosen time, or reactively with low latency and no delay. Putatively preparatory events were conserved across all contexts. Our findings support the hypothesis that an appropriate preparatory state is consistently achieved before movement onset. However, our results reveal that this process can consume surprisingly little time.
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spelling pubmed-61128542018-08-30 Conservation of preparatory neural events in monkey motor cortex regardless of how movement is initiated Lara, Antonio H Elsayed, Gamaleldin F Zimnik, Andrew J Cunningham, John P Churchland, Mark M eLife Neuroscience A time-consuming preparatory stage is hypothesized to precede voluntary movement. A putative neural substrate of motor preparation occurs when a delay separates instruction and execution cues. When readiness is sustained during the delay, sustained neural activity is observed in motor and premotor areas. Yet whether delay-period activity reflects an essential preparatory stage is controversial. In particular, it has remained ambiguous whether delay-period-like activity appears before non-delayed movements. To overcome that ambiguity, we leveraged a recently developed analysis method that parses population responses into putatively preparatory and movement-related components. We examined cortical responses when reaches were initiated after an imposed delay, at a self-chosen time, or reactively with low latency and no delay. Putatively preparatory events were conserved across all contexts. Our findings support the hypothesis that an appropriate preparatory state is consistently achieved before movement onset. However, our results reveal that this process can consume surprisingly little time. eLife Sciences Publications, Ltd 2018-08-22 /pmc/articles/PMC6112854/ /pubmed/30132759 http://dx.doi.org/10.7554/eLife.31826 Text en © 2018, Lara et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Lara, Antonio H
Elsayed, Gamaleldin F
Zimnik, Andrew J
Cunningham, John P
Churchland, Mark M
Conservation of preparatory neural events in monkey motor cortex regardless of how movement is initiated
title Conservation of preparatory neural events in monkey motor cortex regardless of how movement is initiated
title_full Conservation of preparatory neural events in monkey motor cortex regardless of how movement is initiated
title_fullStr Conservation of preparatory neural events in monkey motor cortex regardless of how movement is initiated
title_full_unstemmed Conservation of preparatory neural events in monkey motor cortex regardless of how movement is initiated
title_short Conservation of preparatory neural events in monkey motor cortex regardless of how movement is initiated
title_sort conservation of preparatory neural events in monkey motor cortex regardless of how movement is initiated
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112854/
https://www.ncbi.nlm.nih.gov/pubmed/30132759
http://dx.doi.org/10.7554/eLife.31826
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