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Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis
BACKGROUND: Whether to conduct enteral nutrition in patients with severe acute pancreatitis (SAP) during the active phase of intestinal stress or to feed during remission remains controversial. This study was aimed to evaluate the efficacy and safety of enteral nutrition within 48 hours after admiss...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112989/ https://www.ncbi.nlm.nih.gov/pubmed/30142782 http://dx.doi.org/10.1097/MD.0000000000011871 |
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author | Song, Jianbo Zhong, Yilong Lu, Xiaoguang Kang, Xin Wang, Yi Guo, Wenxiu Liu, Jie Yang, Yilun Pei, Liying |
author_facet | Song, Jianbo Zhong, Yilong Lu, Xiaoguang Kang, Xin Wang, Yi Guo, Wenxiu Liu, Jie Yang, Yilun Pei, Liying |
author_sort | Song, Jianbo |
collection | PubMed |
description | BACKGROUND: Whether to conduct enteral nutrition in patients with severe acute pancreatitis (SAP) during the active phase of intestinal stress or to feed during remission remains controversial. This study was aimed to evaluate the efficacy and safety of enteral nutrition within 48 hours after admission in the patients with SAP or predicted severe acute pancreatitis (pSAP). METHODS: We searched PubMed, EMBASE, Web of Science, and the Cochrane Library before December 2017. Randomized controlled trials of early enteral nutrition (starting within 48 hours after admission) versus late enteral nutrition or total parental nutrition in severe acute pancreatitis or predicted severe acute pancreatitis were selected. RESULTS: Ten randomized controlled trials containing 1051 patients were included. Comparing early enteral nutrition to late enteral nutrition or total parental nutrition in SAP or pSAP, the pooled risk ratios were 0.53 (95% confidence interval [CI] 0.35–0.81, P = .003) for mortality, 0.58 (95% CI 0.43–0.77, P = .0002) for multiple organ failure (MOF), 0.50 (95% CI 0.33–0.75, P = .0008) for operative intervention, 0.75 (95% CI 0.61–0.93, P = .009) for systemic infection, 0.42 (95% CI 0.26–0.69, P = .0005) for local septic complications, 0.84 (95% CI 0.74–0.96, P = .01) for gastrointestinal symptoms. 0.87 (95% CI 0.74–1.02, P = .08) for systemic inflammatory response syndrome (SIRS), and 1.24 (95% CI 0.66–2.31, P = .50) for other local complications. CONCLUSIONS: Enteral nutrition within 48 hours after admission is efficient and safe for the patients with SAP or pSAP. |
format | Online Article Text |
id | pubmed-6112989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-61129892018-09-07 Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis Song, Jianbo Zhong, Yilong Lu, Xiaoguang Kang, Xin Wang, Yi Guo, Wenxiu Liu, Jie Yang, Yilun Pei, Liying Medicine (Baltimore) Research Article BACKGROUND: Whether to conduct enteral nutrition in patients with severe acute pancreatitis (SAP) during the active phase of intestinal stress or to feed during remission remains controversial. This study was aimed to evaluate the efficacy and safety of enteral nutrition within 48 hours after admission in the patients with SAP or predicted severe acute pancreatitis (pSAP). METHODS: We searched PubMed, EMBASE, Web of Science, and the Cochrane Library before December 2017. Randomized controlled trials of early enteral nutrition (starting within 48 hours after admission) versus late enteral nutrition or total parental nutrition in severe acute pancreatitis or predicted severe acute pancreatitis were selected. RESULTS: Ten randomized controlled trials containing 1051 patients were included. Comparing early enteral nutrition to late enteral nutrition or total parental nutrition in SAP or pSAP, the pooled risk ratios were 0.53 (95% confidence interval [CI] 0.35–0.81, P = .003) for mortality, 0.58 (95% CI 0.43–0.77, P = .0002) for multiple organ failure (MOF), 0.50 (95% CI 0.33–0.75, P = .0008) for operative intervention, 0.75 (95% CI 0.61–0.93, P = .009) for systemic infection, 0.42 (95% CI 0.26–0.69, P = .0005) for local septic complications, 0.84 (95% CI 0.74–0.96, P = .01) for gastrointestinal symptoms. 0.87 (95% CI 0.74–1.02, P = .08) for systemic inflammatory response syndrome (SIRS), and 1.24 (95% CI 0.66–2.31, P = .50) for other local complications. CONCLUSIONS: Enteral nutrition within 48 hours after admission is efficient and safe for the patients with SAP or pSAP. Wolters Kluwer Health 2018-08-24 /pmc/articles/PMC6112989/ /pubmed/30142782 http://dx.doi.org/10.1097/MD.0000000000011871 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Song, Jianbo Zhong, Yilong Lu, Xiaoguang Kang, Xin Wang, Yi Guo, Wenxiu Liu, Jie Yang, Yilun Pei, Liying Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis |
title | Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis |
title_full | Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis |
title_fullStr | Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis |
title_full_unstemmed | Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis |
title_short | Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis |
title_sort | enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112989/ https://www.ncbi.nlm.nih.gov/pubmed/30142782 http://dx.doi.org/10.1097/MD.0000000000011871 |
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