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Cognitive decline and white matter changes in mesial temporal lobe epilepsy

Noninvasive imaging plays a pivotal role in assessing the brain structural and functional changes in presurgical mesial temporal lobe epilepsy (MTLE) patients. Our goal was to study the relationship between the changes of cerebral white matter (WM) and cognitive functions in MTLE patients. Voxel-bas...

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Autores principales: Xu, Shang-wen, Xi, Ji-hui, Lin, Chen, Wang, Xiao-yang, Fu, Li-yuan, Kralik, Stephen Francis, Chen, Zi-qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113048/
https://www.ncbi.nlm.nih.gov/pubmed/30113469
http://dx.doi.org/10.1097/MD.0000000000011803
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author Xu, Shang-wen
Xi, Ji-hui
Lin, Chen
Wang, Xiao-yang
Fu, Li-yuan
Kralik, Stephen Francis
Chen, Zi-qian
author_facet Xu, Shang-wen
Xi, Ji-hui
Lin, Chen
Wang, Xiao-yang
Fu, Li-yuan
Kralik, Stephen Francis
Chen, Zi-qian
author_sort Xu, Shang-wen
collection PubMed
description Noninvasive imaging plays a pivotal role in assessing the brain structural and functional changes in presurgical mesial temporal lobe epilepsy (MTLE) patients. Our goal was to study the relationship between the changes of cerebral white matter (WM) and cognitive functions in MTLE patients. Voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) MRI were performed on 24 right-handed MTLE patients (12 with left MTLE and 12 with right MTLE) and 12 matching healthy controls. Gray matter (GM), WM, and whole brain (WB) volumes were measured with VBM while fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were measured with TBSS. All patients and controls also underwent Montreal Cognitive Assessment (MoCA) before MRI. WM volume and the ratio of WM volume versus WB volume were significantly lower in MTLE patients compared with controls. WM volume in MTLE patients had a positive correlation with MoCA score (r = 0.71, P < .001) and a negative correlation with the duration of epilepsy (r = −0.693, P < .001). Volumetric differences were mainly located in the corpus callosum, uncinate fasciculus, inferior longitudinal fasciculus, and superior longitudinal fasciculus. FA of both left MTLE and right MTLE groups was significantly decreased, while MD, AD, and RD were significantly increased. Most left MTLE patients showed bilateral WM fiber tract changes versus ipsilateral changes for right MTLE patients. Changes in DTI parameters and WM volume were found in MTLE patients and more ipsilateral changes were seen with right-sided MTLE. Cognitive changes of MTLE patients were found to be correlated with the changes in WM structure. These findings not only provide useful information for lateralization of the seizure focus but can also be used to explain functional connectivity disorders which may be an important physiological basis for cognitive changes in patients with MTLE.
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spelling pubmed-61130482018-09-07 Cognitive decline and white matter changes in mesial temporal lobe epilepsy Xu, Shang-wen Xi, Ji-hui Lin, Chen Wang, Xiao-yang Fu, Li-yuan Kralik, Stephen Francis Chen, Zi-qian Medicine (Baltimore) Research Article Noninvasive imaging plays a pivotal role in assessing the brain structural and functional changes in presurgical mesial temporal lobe epilepsy (MTLE) patients. Our goal was to study the relationship between the changes of cerebral white matter (WM) and cognitive functions in MTLE patients. Voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) MRI were performed on 24 right-handed MTLE patients (12 with left MTLE and 12 with right MTLE) and 12 matching healthy controls. Gray matter (GM), WM, and whole brain (WB) volumes were measured with VBM while fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were measured with TBSS. All patients and controls also underwent Montreal Cognitive Assessment (MoCA) before MRI. WM volume and the ratio of WM volume versus WB volume were significantly lower in MTLE patients compared with controls. WM volume in MTLE patients had a positive correlation with MoCA score (r = 0.71, P < .001) and a negative correlation with the duration of epilepsy (r = −0.693, P < .001). Volumetric differences were mainly located in the corpus callosum, uncinate fasciculus, inferior longitudinal fasciculus, and superior longitudinal fasciculus. FA of both left MTLE and right MTLE groups was significantly decreased, while MD, AD, and RD were significantly increased. Most left MTLE patients showed bilateral WM fiber tract changes versus ipsilateral changes for right MTLE patients. Changes in DTI parameters and WM volume were found in MTLE patients and more ipsilateral changes were seen with right-sided MTLE. Cognitive changes of MTLE patients were found to be correlated with the changes in WM structure. These findings not only provide useful information for lateralization of the seizure focus but can also be used to explain functional connectivity disorders which may be an important physiological basis for cognitive changes in patients with MTLE. Wolters Kluwer Health 2018-08-17 /pmc/articles/PMC6113048/ /pubmed/30113469 http://dx.doi.org/10.1097/MD.0000000000011803 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Research Article
Xu, Shang-wen
Xi, Ji-hui
Lin, Chen
Wang, Xiao-yang
Fu, Li-yuan
Kralik, Stephen Francis
Chen, Zi-qian
Cognitive decline and white matter changes in mesial temporal lobe epilepsy
title Cognitive decline and white matter changes in mesial temporal lobe epilepsy
title_full Cognitive decline and white matter changes in mesial temporal lobe epilepsy
title_fullStr Cognitive decline and white matter changes in mesial temporal lobe epilepsy
title_full_unstemmed Cognitive decline and white matter changes in mesial temporal lobe epilepsy
title_short Cognitive decline and white matter changes in mesial temporal lobe epilepsy
title_sort cognitive decline and white matter changes in mesial temporal lobe epilepsy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113048/
https://www.ncbi.nlm.nih.gov/pubmed/30113469
http://dx.doi.org/10.1097/MD.0000000000011803
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