Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress

Several studies implicate specific death receptors (DRs) and caspase-8 in mediating apoptosis in response to endoplasmic reticulum (ER) stress; however, a recent paper challenges this conclusion. Here we validate the importance of DR5 and caspase-8 as critical signal conduits for apoptosis activatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Lam, Mable, Lawrence, David A., Ashkenazi, Avi, Walter, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113221/
https://www.ncbi.nlm.nih.gov/pubmed/29991746
http://dx.doi.org/10.1038/s41418-018-0155-y
_version_ 1783350971547516928
author Lam, Mable
Lawrence, David A.
Ashkenazi, Avi
Walter, Peter
author_facet Lam, Mable
Lawrence, David A.
Ashkenazi, Avi
Walter, Peter
author_sort Lam, Mable
collection PubMed
description Several studies implicate specific death receptors (DRs) and caspase-8 in mediating apoptosis in response to endoplasmic reticulum (ER) stress; however, a recent paper challenges this conclusion. Here we validate the importance of DR5 and caspase-8 as critical signal conduits for apoptosis activation upon ER stress.
format Online
Article
Text
id pubmed-6113221
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-61132212018-08-29 Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress Lam, Mable Lawrence, David A. Ashkenazi, Avi Walter, Peter Cell Death Differ Correspondence Several studies implicate specific death receptors (DRs) and caspase-8 in mediating apoptosis in response to endoplasmic reticulum (ER) stress; however, a recent paper challenges this conclusion. Here we validate the importance of DR5 and caspase-8 as critical signal conduits for apoptosis activation upon ER stress. Nature Publishing Group UK 2018-07-10 2018-08 /pmc/articles/PMC6113221/ /pubmed/29991746 http://dx.doi.org/10.1038/s41418-018-0155-y Text en © ADMC Associazione Differenziamento e Morte Cellulare 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Correspondence
Lam, Mable
Lawrence, David A.
Ashkenazi, Avi
Walter, Peter
Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress
title Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress
title_full Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress
title_fullStr Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress
title_full_unstemmed Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress
title_short Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress
title_sort confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113221/
https://www.ncbi.nlm.nih.gov/pubmed/29991746
http://dx.doi.org/10.1038/s41418-018-0155-y
work_keys_str_mv AT lammable confirmingacriticalrolefordeathreceptor5andcaspase8inapoptosisinductionbyendoplasmicreticulumstress
AT lawrencedavida confirmingacriticalrolefordeathreceptor5andcaspase8inapoptosisinductionbyendoplasmicreticulumstress
AT ashkenaziavi confirmingacriticalrolefordeathreceptor5andcaspase8inapoptosisinductionbyendoplasmicreticulumstress
AT walterpeter confirmingacriticalrolefordeathreceptor5andcaspase8inapoptosisinductionbyendoplasmicreticulumstress

Ejemplares similares