The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity

Chronic intoxication of mice with the porphyrinogenic compound 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) leads to morphological and metabolic changes closely resembling steatohepatitis, a severe form of metabolic liver disease in humans. Since human steatohepatitis (both the alcoholic and non-...

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Detalles Bibliográficos
Autores principales: Nikam, Aniket, Patankar, Jay V., Somlapura, Meghana, Lahiri, Pooja, Sachdev, Vinay, Kratky, Dagmar, Denk, Helmut, Zatloukal, Kurt, Abuja, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113278/
https://www.ncbi.nlm.nih.gov/pubmed/30154499
http://dx.doi.org/10.1038/s41598-018-31389-3

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