Cargando…
Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
The Unc-51 like autophagy activating kinase 1 (ULK1) complex plays a central role in the initiation stage of autophagy. However, the function of ULK1 in the late stage of autophagy is unknown. Here, we report that ULK1, a central kinase of the ULK1 complex involved in autophagy initiation, promotes...
Autores principales: | Wang, Chenyao, Wang, Huafei, Zhang, Deyi, Luo, Wenwen, Liu, Ruilong, Xu, Daqian, Diao, Lei, Liao, Lujian, Liu, Zhixue |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113293/ https://www.ncbi.nlm.nih.gov/pubmed/30154410 http://dx.doi.org/10.1038/s41467-018-05449-1 |
Ejemplares similares
-
Macroautophagy and Chaperone-Mediated Autophagy in Heart Failure: The Known and the Unknown
por: Ghosh, Rajeshwary, et al.
Publicado: (2018) -
The Role of Macroautophagy and Chaperone-Mediated Autophagy in the Pathogenesis and Management of Hepatocellular Carcinoma
por: Karampa, Anastasia D., et al.
Publicado: (2022) -
Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases
por: Wu, Haijian, et al.
Publicado: (2014) -
ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases
por: Anwar, Tahira, et al.
Publicado: (2019) -
Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery
por: Backe, Sarah J., et al.
Publicado: (2023)