Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid

13-cis-retinoic acid (isotretinoin, INN) is an oral pharmaceutical drug used for the treatment of skin acne, and is also a known teratogen. In this study, the molecular mechanisms underlying INN-induced developmental toxicity during early cardiac differentiation were investigated using both human in...

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Detalles Bibliográficos
Autores principales: Liu, Qing, Van Bortle, Kevin, Zhang, Yue, Zhao, Ming-Tao, Zhang, Joe Z., Geller, Benjamin S., Gruber, Joshua J., Jiang, Chao, Wu, Joseph C., Snyder, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113333/
https://www.ncbi.nlm.nih.gov/pubmed/30154523
http://dx.doi.org/10.1038/s41598-018-31192-0

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