Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas

Autophagy plays a critical role in tumorigenesis, but how autophagy contributes to cancer cells’ responses to chemotherapeutics remains controversial. To investigate the roles of autophagy in malignant gliomas, we used CRISPR/CAS9 to knock out the ATG5 gene, which is essential for autophagosome form...

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Detalles Bibliográficos
Autores principales: Vu, Ha Thi, Kobayashi, Masahiko, Hegazy, Ahmed M., Tadokoro, Yuko, Ueno, Masaya, Kasahara, Atsuko, Takase, Yusuke, Nomura, Naho, Peng, Hui, Ito, Chiaki, Ino, Yasushi, Todo, Tomoki, Nakada, Mitsutoshi, Hirao, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113445/
https://www.ncbi.nlm.nih.gov/pubmed/29902340
http://dx.doi.org/10.1111/cas.13695

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