Serial Coronary Imaging of Early Atherosclerosis Development in Fast-Food-Fed Diabetic and Nondiabetic Swine

Patients with diabetes mellitus (DM) are at increased risk for atherosclerosis-related events compared to non-DM (NDM) patients. With an expected worldwide epidemic of DM, early detection of anatomic and functional coronary atherosclerotic changes is gaining attention. To improve our understanding o...

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Detalles Bibliográficos
Autores principales: van Ditzhuijzen, Nienke S., van den Heuvel, Mieke, Sorop, Oana, Rossi, Alexia, Veldhof, Timothy, Bruining, Nico, Roest, Stefan, Ligthart, Jurgen M.R., Witberg, Karen Th., Dijkshoorn, Marcel L., Nieman, Koen, Mulder, Monique T., Zijlstra, Felix, Duncker, Dirk J., van Beusekom, Heleen M.M., Regar, Evelyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113514/
https://www.ncbi.nlm.nih.gov/pubmed/30167532
http://dx.doi.org/10.1016/j.jacbts.2016.08.006
Descripción
Sumario:Patients with diabetes mellitus (DM) are at increased risk for atherosclerosis-related events compared to non-DM (NDM) patients. With an expected worldwide epidemic of DM, early detection of anatomic and functional coronary atherosclerotic changes is gaining attention. To improve our understanding of early atherosclerosis development, we studied a swine model that gradually developed coronary atherosclerosis. Interestingly, optical coherence tomography, near-infrared spectroscopy (NIRS), vascular function, and histology demonstrated no differences between development of early atherosclerosis in fast-food-fed (FF) DM swine and that in FF-NDM swine. Coronary computed tomography angiography did not detect early atherosclerosis, but optical coherence tomography and near-infrared spectroscopy demonstrated coronary atherosclerosis development in FF-DM and FF-NDM swine.

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