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Myeloperoxidase Inhibition Improves Ventricular Function and Remodeling After Experimental Myocardial Infarction

PF-1355 is an oral myeloperoxidase (MPO) inhibitor that successfully decreased elevated MPO activity in mouse myocardial infarction models. Short duration PF-1355 treatment for 7 days decreased the number of inflammatory cells and attenuated left ventricular dilation. Cardiac function and remodeling...

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Detalles Bibliográficos
Autores principales:	Ali, Muhammad, Pulli, Benjamin, Courties, Gabriel, Tricot, Benoit, Sebas, Matthew, Iwamoto, Yoshiko, Hilgendorf, Ingo, Schob, Stefan, Dong, Anping, Zheng, Wei, Skoura, Athanasia, Kalgukar, Amit, Cortes, Christian, Ruggeri, Roger, Swirski, Filip K., Nahrendorf, Matthias, Buckbinder, Leonard, Chen, John W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	PRECLINICAL RESEARCH
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113523/ https://www.ncbi.nlm.nih.gov/pubmed/30167547 http://dx.doi.org/10.1016/j.jacbts.2016.09.004

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