Circulating PCSK9 and Risk of Myocardial Infarction: The HUNT Study in Norway

The usefulness of circulating proprotein convertase subtilisin-kexin type 9 (PCSK9) as a risk marker of coronary heart disease in the general population remains unclear. In a nested case-control study in Norway, 1,488 incident myocardial infarctions were registered during 11.3 years of follow-up and...

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Autores principales: Laugsand, Lars E., Åsvold, Bjørn O., Vatten, Lars J., Janszky, Imre, Platou, Carl G., Michelsen, Annika E., Damås, Jan K., Aukrust, Pål, Ueland, Thor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
CLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113535/
https://www.ncbi.nlm.nih.gov/pubmed/30167541
http://dx.doi.org/10.1016/j.jacbts.2016.06.007
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author Laugsand, Lars E.
Åsvold, Bjørn O.
Vatten, Lars J.
Janszky, Imre
Platou, Carl G.
Michelsen, Annika E.
Damås, Jan K.
Aukrust, Pål
Ueland, Thor
author_facet Laugsand, Lars E.
Åsvold, Bjørn O.
Vatten, Lars J.
Janszky, Imre
Platou, Carl G.
Michelsen, Annika E.
Damås, Jan K.
Aukrust, Pål
Ueland, Thor
author_sort Laugsand, Lars E.
collection PubMed
description The usefulness of circulating proprotein convertase subtilisin-kexin type 9 (PCSK9) as a risk marker of coronary heart disease in the general population remains unclear. In a nested case-control study in Norway, 1,488 incident myocardial infarctions were registered during 11.3 years of follow-up and compared with 3,819 controls. Compared with participants in the lowest quartile of PCSK9, myocardial infarction risk was 47% higher in the highest quartile after adjustment for age and sex. After additional adjustment for low-density lipoprotein cholesterol, the association was strongly attenuated. Thus, circulating PCSK9 does not contribute useful information in the assessment of myocardial infarction risk in the general population beyond the information provided by lipid measurements.
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spelling pubmed-61135352018-08-30 Circulating PCSK9 and Risk of Myocardial Infarction: The HUNT Study in Norway Laugsand, Lars E. Åsvold, Bjørn O. Vatten, Lars J. Janszky, Imre Platou, Carl G. Michelsen, Annika E. Damås, Jan K. Aukrust, Pål Ueland, Thor JACC Basic Transl Sci CLINICAL RESEARCH The usefulness of circulating proprotein convertase subtilisin-kexin type 9 (PCSK9) as a risk marker of coronary heart disease in the general population remains unclear. In a nested case-control study in Norway, 1,488 incident myocardial infarctions were registered during 11.3 years of follow-up and compared with 3,819 controls. Compared with participants in the lowest quartile of PCSK9, myocardial infarction risk was 47% higher in the highest quartile after adjustment for age and sex. After additional adjustment for low-density lipoprotein cholesterol, the association was strongly attenuated. Thus, circulating PCSK9 does not contribute useful information in the assessment of myocardial infarction risk in the general population beyond the information provided by lipid measurements. Elsevier 2016-11-30 /pmc/articles/PMC6113535/ /pubmed/30167541 http://dx.doi.org/10.1016/j.jacbts.2016.06.007 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle CLINICAL RESEARCH
Laugsand, Lars E.
Åsvold, Bjørn O.
Vatten, Lars J.
Janszky, Imre
Platou, Carl G.
Michelsen, Annika E.
Damås, Jan K.
Aukrust, Pål
Ueland, Thor
Circulating PCSK9 and Risk of Myocardial Infarction: The HUNT Study in Norway
title Circulating PCSK9 and Risk of Myocardial Infarction: The HUNT Study in Norway
title_full Circulating PCSK9 and Risk of Myocardial Infarction: The HUNT Study in Norway
title_fullStr Circulating PCSK9 and Risk of Myocardial Infarction: The HUNT Study in Norway
title_full_unstemmed Circulating PCSK9 and Risk of Myocardial Infarction: The HUNT Study in Norway
title_short Circulating PCSK9 and Risk of Myocardial Infarction: The HUNT Study in Norway
title_sort circulating pcsk9 and risk of myocardial infarction: the hunt study in norway
topic CLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113535/
https://www.ncbi.nlm.nih.gov/pubmed/30167541
http://dx.doi.org/10.1016/j.jacbts.2016.06.007
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