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Ticagrelor Removal From Human Blood
The authors devised an efficient method for ticagrelor removal from blood using sorbent hemadsorption. Ticagrelor removal was measured in 2 sets of in vitro experiments. The first set was a first-pass experiment using bovine serum albumin (BSA) solution pre-incubated with ticagrelor, whereas the sec...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113557/ https://www.ncbi.nlm.nih.gov/pubmed/30167561 http://dx.doi.org/10.1016/j.jacbts.2017.01.007 |
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author | Angheloiu, George O. Gugiu, Gabriel B. Ruse, Cristian Pandey, Rishikesh Dasari, Ramachandra R. Whatling, Carl |
author_facet | Angheloiu, George O. Gugiu, Gabriel B. Ruse, Cristian Pandey, Rishikesh Dasari, Ramachandra R. Whatling, Carl |
author_sort | Angheloiu, George O. |
collection | PubMed |
description | The authors devised an efficient method for ticagrelor removal from blood using sorbent hemadsorption. Ticagrelor removal was measured in 2 sets of in vitro experiments. The first set was a first-pass experiment using bovine serum albumin (BSA) solution pre-incubated with ticagrelor, whereas the second set, performed in a recirculating manner, used human blood mixed with ticagrelor. Removal of ticagrelor from BSA solution reached values >99%. The peak removal rate was 99% and 94% from whole blood and 99.99% and 90% from plasma during 10 h and 3 to 4 h of recirculating experiments, respectively. In conclusion, hemadsorption robustly removes ticagrelor from BSA solution and human blood samples. |
format | Online Article Text |
id | pubmed-6113557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-61135572018-08-30 Ticagrelor Removal From Human Blood Angheloiu, George O. Gugiu, Gabriel B. Ruse, Cristian Pandey, Rishikesh Dasari, Ramachandra R. Whatling, Carl JACC Basic Transl Sci PRECLINICAL RESEARCH The authors devised an efficient method for ticagrelor removal from blood using sorbent hemadsorption. Ticagrelor removal was measured in 2 sets of in vitro experiments. The first set was a first-pass experiment using bovine serum albumin (BSA) solution pre-incubated with ticagrelor, whereas the second set, performed in a recirculating manner, used human blood mixed with ticagrelor. Removal of ticagrelor from BSA solution reached values >99%. The peak removal rate was 99% and 94% from whole blood and 99.99% and 90% from plasma during 10 h and 3 to 4 h of recirculating experiments, respectively. In conclusion, hemadsorption robustly removes ticagrelor from BSA solution and human blood samples. Elsevier 2017-04-24 /pmc/articles/PMC6113557/ /pubmed/30167561 http://dx.doi.org/10.1016/j.jacbts.2017.01.007 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | PRECLINICAL RESEARCH Angheloiu, George O. Gugiu, Gabriel B. Ruse, Cristian Pandey, Rishikesh Dasari, Ramachandra R. Whatling, Carl Ticagrelor Removal From Human Blood |
title | Ticagrelor Removal From Human Blood |
title_full | Ticagrelor Removal From Human Blood |
title_fullStr | Ticagrelor Removal From Human Blood |
title_full_unstemmed | Ticagrelor Removal From Human Blood |
title_short | Ticagrelor Removal From Human Blood |
title_sort | ticagrelor removal from human blood |
topic | PRECLINICAL RESEARCH |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113557/ https://www.ncbi.nlm.nih.gov/pubmed/30167561 http://dx.doi.org/10.1016/j.jacbts.2017.01.007 |
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