Cargando…

Andecaliximab [Anti-matrix Metalloproteinase-9] Induction Therapy for Ulcerative Colitis: A Randomised, Double-Blind, Placebo-Controlled, Phase 2/3 Study in Patients With Moderate to Severe Disease

BACKGROUND AND AIMS: Matrix metalloproteinase-9 [MMP9] is implicated in the pathogenesis of ulcerative colitis [UC] via disruption of intestinal barrier integrity and function. A phase 2/3 combined trial was designed to examine the efficacy, safety, and pharmacokinetics of the anti-MMP9 antibody, an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sandborn, William J, Bhandari, Bal R, Randall, Charles, Younes, Ziad H, Romanczyk, Tomasz, Xin, Yan, Wendt, Emily, Chai, Hao, McKevitt, Matt, Zhao, Sally, Sundy, John S, Keshav, Satish, Danese, Silvio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113706/ https://www.ncbi.nlm.nih.gov/pubmed/29767728 http://dx.doi.org/10.1093/ecco-jcc/jjy049

Ejemplares similares

A Phase 2, Randomized, Placebo-Controlled Study Evaluating Matrix Metalloproteinase-9 Inhibitor, Andecaliximab, in Patients With Moderately to Severely Active Crohn’s Disease
por: Schreiber, Stefan, et al.
Publicado: (2018)

A phase 1b study of andecaliximab in combination with S-1 plus platinum in Japanese patients with gastric adenocarcinoma
por: Ooki, Akira, et al.
Publicado: (2022)

Randomised clinical trial: a phase 1, dose‐ranging study of the anti‐matrix metalloproteinase‐9 monoclonal antibody GS‐5745 versus placebo for ulcerative colitis
por: Sandborn, W. J., et al.
Publicado: (2016)

Predictors of Sustained Response With Tofacitinib Therapy in Patients With Ulcerative Colitis
por: Sandborn, William J, et al.
Publicado: (2021)

Randomised clinical trial: a phase 1b study of GB004, an oral HIF‐1α stabiliser, for treatment of ulcerative colitis
por: Danese, Silvio, et al.
Publicado: (2022)

Configuring the patient as clinical research subject in the UK national health service
por: Adams, Mary, et al.
Publicado: (2015)

The Possibilities and Limits of “Co-producing” Research
por: Paylor, Jonathan, et al.
Publicado: (2019)

A Case of Difficult Arterial Cannulation: Is Intra-Arterial Blood Pressure Monitoring an Absolute Requirement for Paediatric Liver Transplantation?
por: McKevitt, Helen, et al.
Publicado: (2023)

Advances in the Surgical Treatment of Breast Cancer
por: Cheifetz, Rona, et al.
Publicado: (2023)

Randomized, open-label, phase 2 study of andecaliximab plus nivolumab versus nivolumab alone in advanced gastric cancer identifies biomarkers associated with survival
por: Shah, Manish A, et al.
Publicado: (2021)

Venous thromboembolic events in the tofacitinib ulcerative colitis clinical development programme
por: Sandborn, William J., et al.
Publicado: (2019)

Analysis of the operation of on farm emergency slaughter of bovine animals in the Republic of Ireland
por: McDermott, Paul, et al.
Publicado: (2016)

Phase III Study to Evaluate Efficacy and Safety of Andecaliximab With mFOLFOX6 as First-Line Treatment in Patients With Advanced Gastric or GEJ Adenocarcinoma (GAMMA-1)
por: Shah, Manish A., et al.
Publicado: (2021)

Safety and tolerability of andecaliximab as monotherapy and in combination with an anti-PD-1 antibody in Japanese patients with gastric or gastroesophageal junction adenocarcinoma: a phase 1b study
por: Yoshikawa, Akie Kimura, et al.
Publicado: (2022)

The safety of vedolizumab for ulcerative colitis and Crohn's disease
por: Colombel, Jean-Frédéric, et al.
Publicado: (2017)

Barriers and opportunities for enhancing patient recruitment and retention in clinical research: findings from an interview study in an NHS academic health science centre
por: Adams, Mary, et al.
Publicado: (2015)

Rethinking the relationship between science and society: Has there been a shift in attitudes to Patient and Public Involvement and Public Engagement in Science in the United Kingdom?
por: Boaz, Annette, et al.
Publicado: (2014)

Perceptions of the uses of routine general practice data beyond individual care in England: a qualitative study
por: Wyatt, David, et al.
Publicado: (2018)

How is the audit of therapy intensity influencing rehabilitation in inpatient stroke units in the UK? An ethnographic study
por: Taylor, Elizabeth, et al.
Publicado: (2018)

Embedding research in health systems: lessons from complexity theory
por: Caffrey, Louise, et al.
Publicado: (2016)

Caring for data: Value creation in a data-intensive research laboratory
por: Pinel, Clémence, et al.
Publicado: (2020)

Resistance Development of Cystic Fibrosis Respiratory Pathogens When Exposed to Fosfomycin and Tobramycin Alone and in Combination under Aerobic and Anaerobic Conditions
por: McCaughey, Gerard, et al.
Publicado: (2013)

CCR9 antagonism: potential in the treatment of Inflammatory Bowel Disease
por: Wendt, Emily, et al.
Publicado: (2015)

Budesonide MMX for the Induction of Remission of Mild to Moderate Ulcerative Colitis: A Pooled Safety Analysis
por: Lichtenstein, Gary R., et al.
Publicado: (2015)

Disease clearance in ulcerative colitis: Is the ultimate therapeutic target?
por: D’Amico, Ferdinando, et al.
Publicado: (2023)

Effects of slaughtering operations on carcass contamination in an Irish pork production plant
por: Wheatley, Paul, et al.
Publicado: (2014)

Lay and health care professional understandings of self-management: A systematic review and narrative synthesis
por: Sadler, Euan, et al.
Publicado: (2014)

On Farm Emergency Slaughter and Emergency Killing of Acutely Injured Cattle: Analysis of Guidelines From Five Jurisdictions
por: McDermott, Paul, et al.
Publicado: (2022)

Practical Primer Addressing Real-World Use Scenarios of Subcutaneous Vedolizumab in Ulcerative Colitis and Crohn’s Disease: Post Hoc Analyses of VISIBLE Studies
por: Sandborn, William J, et al.
Publicado: (2023)

Patient‐initiated recruitment for clinical research: Evaluation of an outpatient letter research statement
por: Wienroth, Matthias, et al.
Publicado: (2017)

“Like a nurse but not a nurse”: Clinical Research Practitioners and the evolution of the clinical research delivery workforce in the NHS
por: Faulkner-Gurstein, Rachel, et al.
Publicado: (2019)

How is rehabilitation with and without an integrated self-management approach perceived by UK community-dwelling stroke survivors? A qualitative process evaluation to explore implementation and contextual variations
por: Jones, Fiona, et al.
Publicado: (2017)

Positioning Filgotinib in the Treatment Algorithm of Moderate to Severe Ulcerative Colitis
por: D’Amico, Ferdinando, et al.
Publicado: (2021)

Once-daily budesonide MMX in active, mild-to-moderate ulcerative colitis: results from the randomised CORE II study
por: Travis, Simon P L, et al.
Publicado: (2014)

Early Intervention in Ulcerative Colitis: Ready for Prime Time?
por: Solitano, Virginia, et al.
Publicado: (2020)

Lay perspectives on hypertension and drug adherence: systematic review of qualitative research
por: Marshall, Iain J, et al.
Publicado: (2012)

‘People like you?’: how people with hypertension make sense of future cardiovascular risk—a qualitative study
por: Marshall, Iain J, et al.
Publicado: (2018)

The immunomodulatory role of matrix metalloproteinases in colitis-associated cancer
por: He, Luying, et al.
Publicado: (2023)

Budesonide Multimatrix Is Efficacious for Mesalamine-refractory, Mild to Moderate Ulcerative Colitis: A Randomised, Placebo-controlled Trial
por: Rubin, David T., et al.
Publicado: (2017)

Randomised clinical trial: a placebo‐controlled study of intravenous golimumab induction therapy for ulcerative colitis
por: Rutgeerts, P., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_te5npi0ik0ja7tudkmpna6lavp