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Hemophagocytic syndrome in a cat

CASE SUMMARY: A 12-year-old male castrated domestic shorthair cat was evaluated for a 10 month history of weight loss. Thin body condition and a grade II/VI systolic parasternal heart murmur was noted during examination. Moderate-to-severe anemia and intermittent thrombocytopenia were identified on...

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Autores principales: Wilkinson, Ashley R, Carr, Susan V, Klahn, Shawna L, Dervisis, Nikolaos G, Hanks, Cory R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113740/
https://www.ncbi.nlm.nih.gov/pubmed/30181894
http://dx.doi.org/10.1177/2055116918795023
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author Wilkinson, Ashley R
Carr, Susan V
Klahn, Shawna L
Dervisis, Nikolaos G
Hanks, Cory R
author_facet Wilkinson, Ashley R
Carr, Susan V
Klahn, Shawna L
Dervisis, Nikolaos G
Hanks, Cory R
author_sort Wilkinson, Ashley R
collection PubMed
description CASE SUMMARY: A 12-year-old male castrated domestic shorthair cat was evaluated for a 10 month history of weight loss. Thin body condition and a grade II/VI systolic parasternal heart murmur was noted during examination. Moderate-to-severe anemia and intermittent thrombocytopenia were identified on serial complete blood counts. Antibodies against feline immunodeficiency virus (FIV) were detected, but vaccination for FIV occurred previously. Echocardiography revealed biatrial and biventricular enlargement, left ventricular hypertrophy and pericardial effusion. Splenomegaly was present on abdominal ultrasound and cytological evaluation revealed macrophagic infiltration with erythrophagocytosis. Cytological evaluation of the bone marrow revealed similar findings. Histopathology of the spleen confirmed hemophagocytosis with no evidence of malignancy. A presumptive diagnosis of hemophagocytic syndrome was made. PCR testing for FIV on the splenic tissue was negative. The cat was treated with lomustine. Disease progression occurred approximately 6 months after diagnosis and the cat was euthanized. RELEVANCE AND NOVEL INFORMATION: To our knowledge, this is one of the few reports describing the diagnosis of hemophagocytic syndrome in a cat.
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spelling pubmed-61137402018-09-04 Hemophagocytic syndrome in a cat Wilkinson, Ashley R Carr, Susan V Klahn, Shawna L Dervisis, Nikolaos G Hanks, Cory R JFMS Open Rep Case Report CASE SUMMARY: A 12-year-old male castrated domestic shorthair cat was evaluated for a 10 month history of weight loss. Thin body condition and a grade II/VI systolic parasternal heart murmur was noted during examination. Moderate-to-severe anemia and intermittent thrombocytopenia were identified on serial complete blood counts. Antibodies against feline immunodeficiency virus (FIV) were detected, but vaccination for FIV occurred previously. Echocardiography revealed biatrial and biventricular enlargement, left ventricular hypertrophy and pericardial effusion. Splenomegaly was present on abdominal ultrasound and cytological evaluation revealed macrophagic infiltration with erythrophagocytosis. Cytological evaluation of the bone marrow revealed similar findings. Histopathology of the spleen confirmed hemophagocytosis with no evidence of malignancy. A presumptive diagnosis of hemophagocytic syndrome was made. PCR testing for FIV on the splenic tissue was negative. The cat was treated with lomustine. Disease progression occurred approximately 6 months after diagnosis and the cat was euthanized. RELEVANCE AND NOVEL INFORMATION: To our knowledge, this is one of the few reports describing the diagnosis of hemophagocytic syndrome in a cat. SAGE Publications 2018-08-27 /pmc/articles/PMC6113740/ /pubmed/30181894 http://dx.doi.org/10.1177/2055116918795023 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Wilkinson, Ashley R
Carr, Susan V
Klahn, Shawna L
Dervisis, Nikolaos G
Hanks, Cory R
Hemophagocytic syndrome in a cat
title Hemophagocytic syndrome in a cat
title_full Hemophagocytic syndrome in a cat
title_fullStr Hemophagocytic syndrome in a cat
title_full_unstemmed Hemophagocytic syndrome in a cat
title_short Hemophagocytic syndrome in a cat
title_sort hemophagocytic syndrome in a cat
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113740/
https://www.ncbi.nlm.nih.gov/pubmed/30181894
http://dx.doi.org/10.1177/2055116918795023
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