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Interconnected clusters of invasive meningococcal disease due to Neisseria meningitidis serogroup C ST-11 (cc11), involving bisexuals and men who have sex with men, with discos and gay-venues hotspots of transmission, Tuscany, Italy, 2015 to 2016

In 2015 an increased incidence of invasive meningococcal disease due to serogroup-C (MenC) occurred in Tuscany, Italy. This led the Regional Health Authority of Tuscany to implement a reactive immunisation campaign and to launch an epidemiological field investigation aiming to address targeted immun...

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Autores principales: Miglietta, Alessandro, Fazio, Cecilia, Neri, Arianna, Pezzotti, Patrizio, Innocenti, Francesco, Azzari, Chiara, Rossolini, Gian Maria, Moriondo, Maria, Nieddu, Francesco, Iannazzo, Stefania, D’Ancona, Fortunato, Maraglino, Francesco Paolo, Guerra, Raniero, Rezza, Giovanni, Voller, Fabio, Stefanelli, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113744/
https://www.ncbi.nlm.nih.gov/pubmed/30153883
http://dx.doi.org/10.2807/1560-7917.ES.2018.23.34.1700636
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author Miglietta, Alessandro
Fazio, Cecilia
Neri, Arianna
Pezzotti, Patrizio
Innocenti, Francesco
Azzari, Chiara
Rossolini, Gian Maria
Moriondo, Maria
Nieddu, Francesco
Iannazzo, Stefania
D’Ancona, Fortunato
Maraglino, Francesco Paolo
Guerra, Raniero
Rezza, Giovanni
Voller, Fabio
Stefanelli, Paola
author_facet Miglietta, Alessandro
Fazio, Cecilia
Neri, Arianna
Pezzotti, Patrizio
Innocenti, Francesco
Azzari, Chiara
Rossolini, Gian Maria
Moriondo, Maria
Nieddu, Francesco
Iannazzo, Stefania
D’Ancona, Fortunato
Maraglino, Francesco Paolo
Guerra, Raniero
Rezza, Giovanni
Voller, Fabio
Stefanelli, Paola
author_sort Miglietta, Alessandro
collection PubMed
description In 2015 an increased incidence of invasive meningococcal disease due to serogroup-C (MenC) occurred in Tuscany, Italy. This led the Regional Health Authority of Tuscany to implement a reactive immunisation campaign and to launch an epidemiological field investigation aiming to address targeted immunisation interventions. In 2011–14, 10 MenC cases had been reported compared with 62 cases in 2015–16. The case fatality rate was 21% (n = 13) and 51 cases (82.3%) were confirmed as C:P1.5–1,10–8:F3–6:ST-11(cc11). Overall, 17 clusters were recognised. Six discos and four gay-venues were found to have a role as transmission-hotspots, having been attended by 20 and 14 cases in the 10 days before symptoms onset. Ten and three cases occurred, respectively, among men who have sex with men (MSM) and bisexual individuals, who were involved in 11 clusters. In addition, heterosexual cases (n = 5) attending gay-venues were also found. Secondary cases were not identified. Molecular typing indicated close relationship with MenC clusters recently described among gay, bisexual and other MSM in Europe and the United States, suggesting a possible international spread of the serogroup-C-variant P1.5–1,10–8:F3–6:ST-11(cc11) in this population-group; however, epidemiological links were not identified. In December 2016, a targeted vaccination campaign involving discos and lesbian, gay, bisexual, and transgender (LGBT) associations was implemented. During 2017, 10 cases of MenC occurred, compared with 32 and 30 cases reported in 2015 and 2016 respectively, suggesting the effectiveness of the reactive and targeted immunisation programmes.
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spelling pubmed-61137442018-09-05 Interconnected clusters of invasive meningococcal disease due to Neisseria meningitidis serogroup C ST-11 (cc11), involving bisexuals and men who have sex with men, with discos and gay-venues hotspots of transmission, Tuscany, Italy, 2015 to 2016 Miglietta, Alessandro Fazio, Cecilia Neri, Arianna Pezzotti, Patrizio Innocenti, Francesco Azzari, Chiara Rossolini, Gian Maria Moriondo, Maria Nieddu, Francesco Iannazzo, Stefania D’Ancona, Fortunato Maraglino, Francesco Paolo Guerra, Raniero Rezza, Giovanni Voller, Fabio Stefanelli, Paola Euro Surveill Surveillance and Outbreak Report In 2015 an increased incidence of invasive meningococcal disease due to serogroup-C (MenC) occurred in Tuscany, Italy. This led the Regional Health Authority of Tuscany to implement a reactive immunisation campaign and to launch an epidemiological field investigation aiming to address targeted immunisation interventions. In 2011–14, 10 MenC cases had been reported compared with 62 cases in 2015–16. The case fatality rate was 21% (n = 13) and 51 cases (82.3%) were confirmed as C:P1.5–1,10–8:F3–6:ST-11(cc11). Overall, 17 clusters were recognised. Six discos and four gay-venues were found to have a role as transmission-hotspots, having been attended by 20 and 14 cases in the 10 days before symptoms onset. Ten and three cases occurred, respectively, among men who have sex with men (MSM) and bisexual individuals, who were involved in 11 clusters. In addition, heterosexual cases (n = 5) attending gay-venues were also found. Secondary cases were not identified. Molecular typing indicated close relationship with MenC clusters recently described among gay, bisexual and other MSM in Europe and the United States, suggesting a possible international spread of the serogroup-C-variant P1.5–1,10–8:F3–6:ST-11(cc11) in this population-group; however, epidemiological links were not identified. In December 2016, a targeted vaccination campaign involving discos and lesbian, gay, bisexual, and transgender (LGBT) associations was implemented. During 2017, 10 cases of MenC occurred, compared with 32 and 30 cases reported in 2015 and 2016 respectively, suggesting the effectiveness of the reactive and targeted immunisation programmes. European Centre for Disease Prevention and Control (ECDC) 2018-08-23 /pmc/articles/PMC6113744/ /pubmed/30153883 http://dx.doi.org/10.2807/1560-7917.ES.2018.23.34.1700636 Text en This article is copyright of The Authors, 2018. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Surveillance and Outbreak Report
Miglietta, Alessandro
Fazio, Cecilia
Neri, Arianna
Pezzotti, Patrizio
Innocenti, Francesco
Azzari, Chiara
Rossolini, Gian Maria
Moriondo, Maria
Nieddu, Francesco
Iannazzo, Stefania
D’Ancona, Fortunato
Maraglino, Francesco Paolo
Guerra, Raniero
Rezza, Giovanni
Voller, Fabio
Stefanelli, Paola
Interconnected clusters of invasive meningococcal disease due to Neisseria meningitidis serogroup C ST-11 (cc11), involving bisexuals and men who have sex with men, with discos and gay-venues hotspots of transmission, Tuscany, Italy, 2015 to 2016
title Interconnected clusters of invasive meningococcal disease due to Neisseria meningitidis serogroup C ST-11 (cc11), involving bisexuals and men who have sex with men, with discos and gay-venues hotspots of transmission, Tuscany, Italy, 2015 to 2016
title_full Interconnected clusters of invasive meningococcal disease due to Neisseria meningitidis serogroup C ST-11 (cc11), involving bisexuals and men who have sex with men, with discos and gay-venues hotspots of transmission, Tuscany, Italy, 2015 to 2016
title_fullStr Interconnected clusters of invasive meningococcal disease due to Neisseria meningitidis serogroup C ST-11 (cc11), involving bisexuals and men who have sex with men, with discos and gay-venues hotspots of transmission, Tuscany, Italy, 2015 to 2016
title_full_unstemmed Interconnected clusters of invasive meningococcal disease due to Neisseria meningitidis serogroup C ST-11 (cc11), involving bisexuals and men who have sex with men, with discos and gay-venues hotspots of transmission, Tuscany, Italy, 2015 to 2016
title_short Interconnected clusters of invasive meningococcal disease due to Neisseria meningitidis serogroup C ST-11 (cc11), involving bisexuals and men who have sex with men, with discos and gay-venues hotspots of transmission, Tuscany, Italy, 2015 to 2016
title_sort interconnected clusters of invasive meningococcal disease due to neisseria meningitidis serogroup c st-11 (cc11), involving bisexuals and men who have sex with men, with discos and gay-venues hotspots of transmission, tuscany, italy, 2015 to 2016
topic Surveillance and Outbreak Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113744/
https://www.ncbi.nlm.nih.gov/pubmed/30153883
http://dx.doi.org/10.2807/1560-7917.ES.2018.23.34.1700636
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