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Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen

Many broadly neutralizing antibodies (bnAbs) against HIV-1 recognize and/or penetrate the glycan shield on native, virion-associated envelope glycoprotein (Env) spikes. The same bnAbs also bind to recombinant, soluble trimeric immunogens based on the SOSIP design. While SOSIP trimers are close struc...

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Detalles Bibliográficos
Autores principales:	Struwe, Weston B., Chertova, Elena, Allen, Joel D., Seabright, Gemma E., Watanabe, Yasunori, Harvey, David J., Medina-Ramirez, Max, Roser, James D., Smith, Rodman, Westcott, David, Keele, Brandon F., Bess, Julian W., Sanders, Rogier W., Lifson, Jeffrey D., Moore, John P., Crispin, Max
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113929/ https://www.ncbi.nlm.nih.gov/pubmed/30134158 http://dx.doi.org/10.1016/j.celrep.2018.07.080

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