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Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility
One understudied function of white adipose tissue (AT) is its role in postprandial lipid buffering. In this study, we demonstrate that mice lacking the adipose tissue-specific transcription factor peroxisome proliferator-activated receptor γ2 (PPARγ2) exhibit a defect in their rate of adipose tissue...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113930/ https://www.ncbi.nlm.nih.gov/pubmed/30134163 http://dx.doi.org/10.1016/j.celrep.2018.07.063 |
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author | Virtue, Sam Petkevicius, Kasparas Moreno-Navarrete, José Maria Jenkins, Benjamin Hart, Daniel Dale, Martin Koulman, Albert Fernández-Real, José Manuel Vidal-Puig, Antonio |
author_facet | Virtue, Sam Petkevicius, Kasparas Moreno-Navarrete, José Maria Jenkins, Benjamin Hart, Daniel Dale, Martin Koulman, Albert Fernández-Real, José Manuel Vidal-Puig, Antonio |
author_sort | Virtue, Sam |
collection | PubMed |
description | One understudied function of white adipose tissue (AT) is its role in postprandial lipid buffering. In this study, we demonstrate that mice lacking the adipose tissue-specific transcription factor peroxisome proliferator-activated receptor γ2 (PPARγ2) exhibit a defect in their rate of adipose tissue lipid storage. Impaired adipose tissue storage rate reduces metabolic flexibility, without compromising fasted glucose tolerance or insulin sensitivity, even following prolonged high-fat feeding. However, acutely overfeeding PPARγ2-KO mice caused a 10-fold increase in insulin levels compared with controls. Although impaired adipose tissue storage rate did not result in insulin resistance in young mice, 1-year-old PPARγ2-KO mice developed skeletal muscle insulin resistance. Our data indicate that failed adipose tissue storage may occur prior to defects in glucose handling and that overfeeding protocols may uncover genes controlling adipose tissue storage rate, as opposed to capacity, and act as a diagnostic test for early-stage human metabolic disease. |
format | Online Article Text |
id | pubmed-6113930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-61139302018-08-30 Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility Virtue, Sam Petkevicius, Kasparas Moreno-Navarrete, José Maria Jenkins, Benjamin Hart, Daniel Dale, Martin Koulman, Albert Fernández-Real, José Manuel Vidal-Puig, Antonio Cell Rep Article One understudied function of white adipose tissue (AT) is its role in postprandial lipid buffering. In this study, we demonstrate that mice lacking the adipose tissue-specific transcription factor peroxisome proliferator-activated receptor γ2 (PPARγ2) exhibit a defect in their rate of adipose tissue lipid storage. Impaired adipose tissue storage rate reduces metabolic flexibility, without compromising fasted glucose tolerance or insulin sensitivity, even following prolonged high-fat feeding. However, acutely overfeeding PPARγ2-KO mice caused a 10-fold increase in insulin levels compared with controls. Although impaired adipose tissue storage rate did not result in insulin resistance in young mice, 1-year-old PPARγ2-KO mice developed skeletal muscle insulin resistance. Our data indicate that failed adipose tissue storage may occur prior to defects in glucose handling and that overfeeding protocols may uncover genes controlling adipose tissue storage rate, as opposed to capacity, and act as a diagnostic test for early-stage human metabolic disease. Cell Press 2018-08-24 /pmc/articles/PMC6113930/ /pubmed/30134163 http://dx.doi.org/10.1016/j.celrep.2018.07.063 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Virtue, Sam Petkevicius, Kasparas Moreno-Navarrete, José Maria Jenkins, Benjamin Hart, Daniel Dale, Martin Koulman, Albert Fernández-Real, José Manuel Vidal-Puig, Antonio Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility |
title | Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility |
title_full | Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility |
title_fullStr | Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility |
title_full_unstemmed | Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility |
title_short | Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility |
title_sort | peroxisome proliferator-activated receptor γ2 controls the rate of adipose tissue lipid storage and determines metabolic flexibility |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113930/ https://www.ncbi.nlm.nih.gov/pubmed/30134163 http://dx.doi.org/10.1016/j.celrep.2018.07.063 |
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