Cargando…

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

Activation of macrophages by inflammatory stimuli induces reprogramming of mitochondrial metabolism to support the production of pro-inflammatory cytokines and nitric oxide. Hallmarks of this metabolic rewiring are downregulation of α-ketoglutarate formation by isocitrate dehydrogenase (IDH) and acc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koenis, Duco Steven, Medzikovic, Lejla, van Loenen, Pieter Bas, van Weeghel, Michel, Huveneers, Stephan, Vos, Mariska, Evers-van Gogh, Ingrid Johanna, Van den Bossche, Jan, Speijer, Dave, Kim, Yongsoo, Wessels, Lodewyk, Zelcer, Noam, Zwart, Wilbert, Kalkhoven, Eric, de Vries, Carlie Jacoba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113932/ https://www.ncbi.nlm.nih.gov/pubmed/30134173 http://dx.doi.org/10.1016/j.celrep.2018.07.065

Ejemplares similares

Nuclear Receptor Nur77 Controls Cardiac Fibrosis through Distinct Actions on Fibroblasts and Cardiomyocytes
por: Medzikovic, Lejla, et al.
Publicado: (2021)

Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance
por: Hamers, Anouk A. J., et al.
Publicado: (2016)

Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling
por: Medzikovic, Lejla, et al.
Publicado: (2015)

‘Nur'turing tumor T cell tolerance and exhaustion: novel function for Nuclear Receptor Nur77 in immunity
por: Lith, Sanne C., et al.
Publicado: (2020)

Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFκB Activity in Macrophages
por: Hamers, Anouk A. J., et al.
Publicado: (2015)

Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function
por: Tel-Karthaus, Nina, et al.
Publicado: (2018)

Regulation of Nuclear Receptor Nur77 by miR-124
por: Tenga, Alexa, et al.
Publicado: (2016)

Nur77 deficiency leads to systemic inflammation in elderly mice
por: Li, Xiu-Ming, et al.
Publicado: (2015)

Characteristics of Nur77 and its ligands as potential anticancer compounds
por: Wu, Lingjuan, et al.
Publicado: (2018)

Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy
por: Hu, Mengjie, et al.
Publicado: (2018)

New Avenues for Antiinflammatory Signaling of Nur77 in Acute Lung Injury
por: Sommer, Natascha, et al.
Publicado: (2021)

Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor–induced Nur77 expression and apoptosis
por: Dequiedt, Franck, et al.
Publicado: (2005)

Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77
por: Chao, Lily C., et al.
Publicado: (2009)

Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization
por: Chao, Lily C., et al.
Publicado: (2012)

Nur77-Tempo mice reveal T cell steady state antigen recognition
por: Elliot, Thomas A. E., et al.
Publicado: (2022)

Progress and Promise of Nur77-based Therapeutics for Central Nervous System Disorders
por: Liu, Lu, et al.
Publicado: (2021)

Dexmedetomidine attenuates inflammation and organ injury partially by upregulating Nur77 in sepsis
por: Zhang, Qian, et al.
Publicado: (2023)

Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity
por: Kurakula, Kondababu, et al.
Publicado: (2018)

Orphan Nuclear Receptor Nur77 Is Involved in Caspase-independent Macrophage Cell Death
por: Kim, Sung Ouk, et al.
Publicado: (2003)

Inhibition of β-catenin Signaling by Nongenomic Action of Orphan Nuclear Receptor Nur77
por: Sun, Zhe, et al.
Publicado: (2011)

Female Nur77-Deficient Mice Show Increased Susceptibility to Diet-Induced Obesity
por: Perez-Sieira, Sonia, et al.
Publicado: (2013)

Modulation of the Nur77-Bcl-2 apoptotic pathway by p38α MAPK
por: Liu, Jie, et al.
Publicado: (2017)

ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis
por: Huo, Jianxin, et al.
Publicado: (2020)

FOXA3, a Negative Regulator of Nur77 Expression and Activity in Testicular Steroidogenesis
por: Kim, Hansle, et al.
Publicado: (2021)

Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish
por: Xu, Yang, et al.
Publicado: (2022)

Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice
por: Cai, Xinyu, et al.
Publicado: (2023)

Hederagenin suppresses glioma cell biological activities via Nur77 in vitro study
por: Dai, Yuxiang, et al.
Publicado: (2022)

Genomic data integration by WON-PARAFAC identifies interpretable factors for predicting drug-sensitivity in vivo
por: Kim, Yongsoo, et al.
Publicado: (2019)

Electric Pulse Stimulation of Myotubes as an In Vitro Exercise Model: Cell-Mediated and Non-Cell-Mediated Effects
por: Evers-van Gogh, Inkie J.A., et al.
Publicado: (2015)

Orphan nuclear receptor TR3/Nur77 regulates VEGF-A–induced angiogenesis through its transcriptional activity
por: Zeng, Huiyan, et al.
Publicado: (2006)

Resistance of Foxp3+ Regulatory T Cells to Nur77-Induced Apoptosis Promotes Allograft Survival
por: Tao, Ran, et al.
Publicado: (2008)

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self- reactive T cells
Publicado: (1996)

Orphan Nuclear Receptor Nur77 Regulates Androgen Receptor Gene Expression in Mouse Ovary
por: Dai, Anyi, et al.
Publicado: (2012)

Human-Gyrovirus-Apoptin Triggers Mitochondrial Death Pathway—Nur77 is Required for Apoptosis Triggering
por: Chaabane, Wiem, et al.
Publicado: (2014)

Simultaneous targeting of MyD88 and Nur77 as an effective approach for the treatment of inflammatory diseases
por: Uzma, Saqib, et al.
Publicado: (2016)

Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
por: Li, Xiu-Ming, et al.
Publicado: (2016)

The Stimulative Effect of Yangjing Capsule on Testosterone Synthesis through Nur77 Pathway in Leydig Cells
por: Gu, Yalong, et al.
Publicado: (2015)

Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice
por: Cortez-Toledo, Omar, et al.
Publicado: (2017)

Cigarette smoke downregulates Nur77 to exacerbate inflammation in chronic obstructive pulmonary disease (COPD)
por: Reddy, Aravind T., et al.
Publicado: (2020)

Cytokine exposure mediates transcriptional activation of the orphan nuclear receptor Nur77 in hematopoietic cells
por: di Martino, Orsola, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9vv55b25aia631j2b5qg72ltfo