Rab GTPases in Osteoclastic Endomembrane Systems

Osteoclasts (OCs) are bone-resorbing cells that maintain bone homeostasis. OC differentiation, survival, and activity are regulated by numerous small GTPases, including those of the Rab family, which are involved in plasma membrane delivery and lysosomal and autophagic degradation pathways. In resor...

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Detalles Bibliográficos
Autores principales: Roy, Michèle, Roux, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114073/
https://www.ncbi.nlm.nih.gov/pubmed/30186859
http://dx.doi.org/10.1155/2018/4541538
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author Roy, Michèle
Roux, Sophie
author_facet Roy, Michèle
Roux, Sophie
author_sort Roy, Michèle
collection PubMed
description Osteoclasts (OCs) are bone-resorbing cells that maintain bone homeostasis. OC differentiation, survival, and activity are regulated by numerous small GTPases, including those of the Rab family, which are involved in plasma membrane delivery and lysosomal and autophagic degradation pathways. In resorbing OCs, polarized vesicular trafficking pathways also result in formation of the ruffled membrane, the resorbing organelle, and in transcytosis.
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spelling pubmed-61140732018-09-05 Rab GTPases in Osteoclastic Endomembrane Systems Roy, Michèle Roux, Sophie Biomed Res Int Review Article Osteoclasts (OCs) are bone-resorbing cells that maintain bone homeostasis. OC differentiation, survival, and activity are regulated by numerous small GTPases, including those of the Rab family, which are involved in plasma membrane delivery and lysosomal and autophagic degradation pathways. In resorbing OCs, polarized vesicular trafficking pathways also result in formation of the ruffled membrane, the resorbing organelle, and in transcytosis. Hindawi 2018-08-15 /pmc/articles/PMC6114073/ /pubmed/30186859 http://dx.doi.org/10.1155/2018/4541538 Text en Copyright © 2018 Michèle Roy and Sophie Roux. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Roy, Michèle
Roux, Sophie
Rab GTPases in Osteoclastic Endomembrane Systems
title Rab GTPases in Osteoclastic Endomembrane Systems
title_full Rab GTPases in Osteoclastic Endomembrane Systems
title_fullStr Rab GTPases in Osteoclastic Endomembrane Systems
title_full_unstemmed Rab GTPases in Osteoclastic Endomembrane Systems
title_short Rab GTPases in Osteoclastic Endomembrane Systems
title_sort rab gtpases in osteoclastic endomembrane systems
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114073/
https://www.ncbi.nlm.nih.gov/pubmed/30186859
http://dx.doi.org/10.1155/2018/4541538
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