Cargando…

Metabolism of albendazole, ricobendazole and flubendazole in Haemonchus contortus adults: Sex differences, resistance-related differences and the identification of new metabolites

Haemonchus contortus (family Trichostrongylidae, Nematoda), a hematophagous gastrointestinal parasite found in small ruminants, has a great ability to develop resistance to anthelmintic drugs. We studied the biotransformation of the three benzimidazole anthelmintics: albendazole (ABZ), ricobendazole...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stuchlíková, Lucie Raisová, Matoušková, Petra, Vokřál, Ivan, Lamka, Jiří, Szotáková, Barbora, Sečkařová, Anna, Dimunová, Diana, Nguyen, Linh Thuy, Várady, Marián, Skálová, Lenka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114105/ https://www.ncbi.nlm.nih.gov/pubmed/29414106 http://dx.doi.org/10.1016/j.ijpddr.2018.01.005

Ejemplares similares

Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults
por: Kellerová, Pavlína, et al.
Publicado: (2020)

UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences
por: Matoušková, Petra, et al.
Publicado: (2018)

UDP-Glycosyltransferases and Albendazole Metabolism in the Juvenile Stages of Haemonchus contortus
por: Kellerová, Pavlína, et al.
Publicado: (2020)

The induction and inhibition of UDP-glycosyltransferases in Haemonchus contortus and their role in the metabolism of albendazole
por: Dimunová, Diana, et al.
Publicado: (2022)

Short-chain dehydrogenases in Haemonchus contortus: changes during life cycle and in relation to drug-resistance
por: Štěrbová, Karolína, et al.
Publicado: (2023)

The Identification of Metabolites and Effects of Albendazole in Alfalfa (Medicago sativa)
por: Raisová Stuchlíková, Lucie, et al.
Publicado: (2020)

Anthelmintic activity of European fern extracts against Haemonchus contortus
por: Pavičić, Antonio, et al.
Publicado: (2023)

Sertraline as a new potential anthelmintic against Haemonchus contortus: toxicity, efficacy, and biotransformation
por: Zajíčková, Markéta, et al.
Publicado: (2021)

The ATP bioluminescence assay: a new application and optimization for viability testing in the parasitic nematode Haemonchus contortus
por: Nguyen, Linh Thuy, et al.
Publicado: (2021)

Carbonyl Reduction of Flubendazole in the Human Liver: Strict Stereospecificity, Sex Difference, Low Risk of Drug Interactions
por: Kubíček, Vladimír, et al.
Publicado: (2019)

The Uptake of Ivermectin and Its Effects in Roots, Leaves and Seeds of Soybean (Glycine max)
por: Navrátilová, Martina, et al.
Publicado: (2020)

Soybean (Glycine max) Is Able to Absorb, Metabolize and Accumulate Fenbendazole in All Organs Including Beans
por: Podlipná, Radka, et al.
Publicado: (2021)

Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation
por: Zajíčková, Markéta, et al.
Publicado: (2022)

Image recognition based on deep learning in Haemonchus contortus motility assays
por: Žofka, Martin, et al.
Publicado: (2022)

Peptidomics of Haemonchus contortus
por: Buzy, Armelle, et al.
Publicado: (2021)

Reference Genes for Real-Time PCR Quantification of Messenger RNAs and MicroRNAs in Mouse Model of Obesity
por: Matoušková, Petra, et al.
Publicado: (2014)

The Modulation of Phase II Drug-Metabolizing Enzymes in Proliferating and Differentiated CaCo-2 Cells by Hop-Derived Prenylflavonoids
por: Lněničková, Kateřina, et al.
Publicado: (2020)

Changes in Haematological Parameters in Wild Ruminants Experimentally Infected with Haemonchus Contortus
por: Sesztáková, E., et al.
Publicado: (2019)

Catechins Variously Affect Activities of Conjugation Enzymes in Proliferating and Differentiated Caco-2 Cells
por: Lněničková, Kateřina, et al.
Publicado: (2016)

Identification and characterisation of the haemozoin of Haemonchus contortus
por: Liu, Lu, et al.
Publicado: (2023)

Does in Vitro and in Vivo Exposure To Medicinal Herbs Cause Structural Cuticular Changes in Haemonchus Contortus?
por: Komáromyová, M., et al.
Publicado: (2022)

Does the in vitro egg hatch test predict the failure of benzimidazole treatment in Haemonchus contortus?
por: Babják, Michal, et al.
Publicado: (2021)

Effects of herbal nutraceuticals and/or zinc against Haemonchus contortus in lambs experimentally infected
por: Váradyová, Zora, et al.
Publicado: (2018)

The Influence of Sesquiterpenes from Myrica rubra on the Antiproliferative and Pro-Oxidative Effects of Doxorubicin and Its Accumulation in Cancer Cells
por: Ambrož, Martin, et al.
Publicado: (2015)

Recent Research Progress in China on Haemonchus contortus
por: Wang, Chunqun, et al.
Publicado: (2017)

Dauer signalling pathway model for Haemonchus contortus
por: Ma, Guangxu, et al.
Publicado: (2019)

Nerolidol and Farnesol Inhibit Some Cytochrome P450 Activities but Did Not Affect Other Xenobiotic-Metabolizing Enzymes in Rat and Human Hepatic Subcellular Fractions
por: Špičáková, Alena, et al.
Publicado: (2017)

Variation in allele frequencies in benzimidazole resistant and susceptible isolates of Haemonchus contortus during patent infection in lambs
por: Dolinská, Michaela Urda, et al.
Publicado: (2023)

Similarities and differences in the biotransformation and transcriptomic responses of Caenorhabditis elegans and Haemonchus contortus to five different benzimidazole drugs
por: Stasiuk, S.J., et al.
Publicado: (2019)

Point of care colourimetric and lateral flow LAMP assay for the detection of Haemonchus contortus in ruminant faecal samples
por: Khangembam, Rojesh, et al.
Publicado: (2021)

Phenotypic screening of the ‘Kurz-box’ of chemicals identifies two compounds (BLK127 and HBK4) with anthelmintic activity in vitro against parasitic larval stages of Haemonchus contortus
por: Nguyen, Linh Thuy, et al.
Publicado: (2019)

Resistance to experimental infections with Haemonchus contortus in Romanov sheep
por: Luffau, G, et al.
Publicado: (1990)

The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus
por: Schwarz, Erich M, et al.
Publicado: (2013)

Inhibition of Haemonchus contortus larval development by fungal lectins
por: Heim, Christian, et al.
Publicado: (2015)

Reconstruction of the insulin-like signalling pathway of Haemonchus contortus
por: Mohandas, Namitha, et al.
Publicado: (2016)

Characterisation of P-glycoprotein-9.1 in Haemonchus contortus
por: Godoy, Pablo, et al.
Publicado: (2016)

Extreme-QTL mapping of monepantel resistance in Haemonchus contortus
por: Niciura, Simone Cristina Méo, et al.
Publicado: (2019)

Signatures of selection for resistance to Haemonchus contortus in sheep and goats
por: Estrada-Reyes, Zaira M., et al.
Publicado: (2019)

Transcriptomics and Proteomics of Haemonchus contortus in Response to Ivermectin Treatment
por: Liu, Yang, et al.
Publicado: (2023)

Sensitivity of Haemonchus contortus to anthelmintics using different in vitro screening assays: a comparative study
por: Munguía, Beatriz, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_e41kftp0l5nt2u4mnas1muktb2