Gonadectomy in Mito-Ob mice revealed a sex-dimorphic relationship between prohibitin and sex steroids in adipose tissue biology and glucose homeostasis

BACKGROUND: Recently, we have developed a novel transgenic mouse model by overexpressing prohibitin (PHB) in adipocytes, which developed obesity due to upregulation of mitochondrial biogenesis in adipocytes, hence named “Mito-Ob.” Interestingly, only male Mito-Ob mice developed obesity-related impai...

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Detalles Bibliográficos
Autores principales: Xu, Yang Xin Zi, Ande, Sudharsana Rao, Mishra, Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114179/
https://www.ncbi.nlm.nih.gov/pubmed/30157935
http://dx.doi.org/10.1186/s13293-018-0196-4

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