Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults

We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection pr...

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Autores principales: Ellis, Jayne, Cresswell, Fiona V, Rhein, Joshua, Ssebambulidde, Kenneth, Boulware, David R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114196/
https://www.ncbi.nlm.nih.gov/pubmed/30182032
http://dx.doi.org/10.1093/ofid/ofy193
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author Ellis, Jayne
Cresswell, Fiona V
Rhein, Joshua
Ssebambulidde, Kenneth
Boulware, David R
author_facet Ellis, Jayne
Cresswell, Fiona V
Rhein, Joshua
Ssebambulidde, Kenneth
Boulware, David R
author_sort Ellis, Jayne
collection PubMed
description We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection prevalence was 0.8% (5/586) among cryptococcal meningitis, 2 during second cryptococcal episodes.
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spelling pubmed-61141962018-09-04 Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults Ellis, Jayne Cresswell, Fiona V Rhein, Joshua Ssebambulidde, Kenneth Boulware, David R Open Forum Infect Dis Brief Report We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection prevalence was 0.8% (5/586) among cryptococcal meningitis, 2 during second cryptococcal episodes. Oxford University Press 2018-08-29 /pmc/articles/PMC6114196/ /pubmed/30182032 http://dx.doi.org/10.1093/ofid/ofy193 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Ellis, Jayne
Cresswell, Fiona V
Rhein, Joshua
Ssebambulidde, Kenneth
Boulware, David R
Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults
title Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults
title_full Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults
title_fullStr Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults
title_full_unstemmed Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults
title_short Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults
title_sort cryptococcal meningitis and tuberculous meningitis co-infection in hiv-infected ugandan adults
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114196/
https://www.ncbi.nlm.nih.gov/pubmed/30182032
http://dx.doi.org/10.1093/ofid/ofy193
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