Cargando…

Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint

Lipid cell membrane composed of various distinct lipids and proteins act as a platform to assemble various signaling complexes regulating innumerous cellular processes which are strongly downregulated or altered in cancer cells emphasizing the still-underestimated critical function of lipid biomolec...

Descripción completa

Detalles Bibliográficos
Autores principales: Srivatsav, Aswin T., Mishra, Manjari, Kapoor, Shobhna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114229/
https://www.ncbi.nlm.nih.gov/pubmed/30186863
http://dx.doi.org/10.1155/2018/6437371
_version_ 1783351151256666112
author Srivatsav, Aswin T.
Mishra, Manjari
Kapoor, Shobhna
author_facet Srivatsav, Aswin T.
Mishra, Manjari
Kapoor, Shobhna
author_sort Srivatsav, Aswin T.
collection PubMed
description Lipid cell membrane composed of various distinct lipids and proteins act as a platform to assemble various signaling complexes regulating innumerous cellular processes which are strongly downregulated or altered in cancer cells emphasizing the still-underestimated critical function of lipid biomolecules in cancer initiation and progression. In this review, we outline the current understanding of how membrane lipids act as signaling hot spots by generating distinct membrane microdomains called rafts to initiate various cellular processes and their modulation in cancer phenotypes. We elucidate tangible drug targets and pathways all amenable to small-molecule perturbation. Ranging from targeting membrane rafts organization/reorganization to rewiring lipid metabolism and lipid sorting in cancer, the work summarized here represents critical intervention points being attempted for lipid-based anticancer therapy and future directions.
format Online
Article
Text
id pubmed-6114229
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-61142292018-09-05 Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint Srivatsav, Aswin T. Mishra, Manjari Kapoor, Shobhna Biomed Res Int Review Article Lipid cell membrane composed of various distinct lipids and proteins act as a platform to assemble various signaling complexes regulating innumerous cellular processes which are strongly downregulated or altered in cancer cells emphasizing the still-underestimated critical function of lipid biomolecules in cancer initiation and progression. In this review, we outline the current understanding of how membrane lipids act as signaling hot spots by generating distinct membrane microdomains called rafts to initiate various cellular processes and their modulation in cancer phenotypes. We elucidate tangible drug targets and pathways all amenable to small-molecule perturbation. Ranging from targeting membrane rafts organization/reorganization to rewiring lipid metabolism and lipid sorting in cancer, the work summarized here represents critical intervention points being attempted for lipid-based anticancer therapy and future directions. Hindawi 2018-08-15 /pmc/articles/PMC6114229/ /pubmed/30186863 http://dx.doi.org/10.1155/2018/6437371 Text en Copyright © 2018 Aswin T. Srivatsav et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Srivatsav, Aswin T.
Mishra, Manjari
Kapoor, Shobhna
Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint
title Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint
title_full Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint
title_fullStr Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint
title_full_unstemmed Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint
title_short Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint
title_sort small-molecule modulation of lipid-dependent cellular processes against cancer: fats on the gunpoint
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114229/
https://www.ncbi.nlm.nih.gov/pubmed/30186863
http://dx.doi.org/10.1155/2018/6437371
work_keys_str_mv AT srivatsavaswint smallmoleculemodulationoflipiddependentcellularprocessesagainstcancerfatsonthegunpoint
AT mishramanjari smallmoleculemodulationoflipiddependentcellularprocessesagainstcancerfatsonthegunpoint
AT kapoorshobhna smallmoleculemodulationoflipiddependentcellularprocessesagainstcancerfatsonthegunpoint