The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention

Vitamin D is a fat-soluble prohormone best known for its role in maintaining calcium homeostasis. Large numbers of epidemiological studies have shown that vitamin D plays an important role in cancer prevention by regulating cellular proliferation and metabolism. Studies of the cellular mechanism of...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Hui, Guo, Jing, Xie, Wenli, Yuan, Lingqin, Sheng, Xiugui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114234/
https://www.ncbi.nlm.nih.gov/pubmed/30157901
http://dx.doi.org/10.1186/s13048-018-0443-7
_version_ 1783351152454139904
author Guo, Hui
Guo, Jing
Xie, Wenli
Yuan, Lingqin
Sheng, Xiugui
author_facet Guo, Hui
Guo, Jing
Xie, Wenli
Yuan, Lingqin
Sheng, Xiugui
author_sort Guo, Hui
collection PubMed
description Vitamin D is a fat-soluble prohormone best known for its role in maintaining calcium homeostasis. Large numbers of epidemiological studies have shown that vitamin D plays an important role in cancer prevention by regulating cellular proliferation and metabolism. Studies of the cellular mechanism of vitamin D in ovarian cancer strongly suggest that it exhibits protective and antitumorigenic activities through genomic and nongenomic signal transduction pathways. These results indicate that vitamin D deficiency results in an increase in the risk of developing ovarian cancer and that vitamin supplements may potentially be an efficient way of preventing cancer. Consequently, this review describes the epidemiology, molecular mechanism and evidence linking vitamin D deficiency to ovarian cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13048-018-0443-7) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-6114234
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-61142342018-09-04 The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention Guo, Hui Guo, Jing Xie, Wenli Yuan, Lingqin Sheng, Xiugui J Ovarian Res Review Vitamin D is a fat-soluble prohormone best known for its role in maintaining calcium homeostasis. Large numbers of epidemiological studies have shown that vitamin D plays an important role in cancer prevention by regulating cellular proliferation and metabolism. Studies of the cellular mechanism of vitamin D in ovarian cancer strongly suggest that it exhibits protective and antitumorigenic activities through genomic and nongenomic signal transduction pathways. These results indicate that vitamin D deficiency results in an increase in the risk of developing ovarian cancer and that vitamin supplements may potentially be an efficient way of preventing cancer. Consequently, this review describes the epidemiology, molecular mechanism and evidence linking vitamin D deficiency to ovarian cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13048-018-0443-7) contains supplementary material, which is available to authorized users. BioMed Central 2018-08-29 /pmc/articles/PMC6114234/ /pubmed/30157901 http://dx.doi.org/10.1186/s13048-018-0443-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Guo, Hui
Guo, Jing
Xie, Wenli
Yuan, Lingqin
Sheng, Xiugui
The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention
title The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention
title_full The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention
title_fullStr The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention
title_full_unstemmed The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention
title_short The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention
title_sort role of vitamin d in ovarian cancer: epidemiology, molecular mechanism and prevention
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114234/
https://www.ncbi.nlm.nih.gov/pubmed/30157901
http://dx.doi.org/10.1186/s13048-018-0443-7
work_keys_str_mv AT guohui theroleofvitamindinovariancancerepidemiologymolecularmechanismandprevention
AT guojing theroleofvitamindinovariancancerepidemiologymolecularmechanismandprevention
AT xiewenli theroleofvitamindinovariancancerepidemiologymolecularmechanismandprevention
AT yuanlingqin theroleofvitamindinovariancancerepidemiologymolecularmechanismandprevention
AT shengxiugui theroleofvitamindinovariancancerepidemiologymolecularmechanismandprevention
AT guohui roleofvitamindinovariancancerepidemiologymolecularmechanismandprevention
AT guojing roleofvitamindinovariancancerepidemiologymolecularmechanismandprevention
AT xiewenli roleofvitamindinovariancancerepidemiologymolecularmechanismandprevention
AT yuanlingqin roleofvitamindinovariancancerepidemiologymolecularmechanismandprevention
AT shengxiugui roleofvitamindinovariancancerepidemiologymolecularmechanismandprevention

Ejemplares similares