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Association of airborne particles, protein, and endotoxin with emergency department visits for asthma in Kyoto, Japan
BACKGROUND: The health effects of biological aerosols on the respiratory system are unclear. The purpose of this study was to clarify the association of airborne particle, protein, and endotoxin with emergency department visits for asthma in Kyoto City, Japan. METHODS: We collected data on emergency...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114267/ https://www.ncbi.nlm.nih.gov/pubmed/30153806 http://dx.doi.org/10.1186/s12199-018-0731-2 |
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author | Khan, Mohammad Shahriar Coulibaly, Souleymane Matsumoto, Takahiro Yano, Yoshitaka Miura, Makoto Nagasaka, Yukio Shima, Masayuki Yamagishi, Nobuyuki Wakabayashi, Keiji Watanabe, Tetsushi |
author_facet | Khan, Mohammad Shahriar Coulibaly, Souleymane Matsumoto, Takahiro Yano, Yoshitaka Miura, Makoto Nagasaka, Yukio Shima, Masayuki Yamagishi, Nobuyuki Wakabayashi, Keiji Watanabe, Tetsushi |
author_sort | Khan, Mohammad Shahriar |
collection | PubMed |
description | BACKGROUND: The health effects of biological aerosols on the respiratory system are unclear. The purpose of this study was to clarify the association of airborne particle, protein, and endotoxin with emergency department visits for asthma in Kyoto City, Japan. METHODS: We collected data on emergency department visits at a hospital in Kyoto from September 2014 to May 2016. Fine (aerodynamic diameter ≤ 2.5 μm) and coarse (≥ 2.5 μm) particles were collected in Kyoto, and protein and endotoxin levels were analyzed. The association of the levels of particles, protein, endotoxin, and meteorological factors (temperature, relative humidity, wind speed, and air pressure) with emergency department visits for asthma was estimated. RESULTS: There were 1 to 15 emergency department visits for asthma per week, and the numbers of visits increased in the autumn and spring, namely many weeks in September, October, and April. Weekly concentration of protein in fine particles was markedly higher than that in coarse particles, and protein concentration in fine particles was high in spring months. Weekly endotoxin concentrations in fine and coarse particles were high in autumn months, including September 2014 and 2015. Even after adjusting for meteorological factors, the concentrations of coarse particles and endotoxin in both particles were significant factors on emergency department visits for asthma. CONCLUSIONS: Our results suggest that atmospheric coarse particles and endotoxin are significantly associated with an increased risk of asthma exacerbation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12199-018-0731-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6114267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61142672018-09-04 Association of airborne particles, protein, and endotoxin with emergency department visits for asthma in Kyoto, Japan Khan, Mohammad Shahriar Coulibaly, Souleymane Matsumoto, Takahiro Yano, Yoshitaka Miura, Makoto Nagasaka, Yukio Shima, Masayuki Yamagishi, Nobuyuki Wakabayashi, Keiji Watanabe, Tetsushi Environ Health Prev Med Research Article BACKGROUND: The health effects of biological aerosols on the respiratory system are unclear. The purpose of this study was to clarify the association of airborne particle, protein, and endotoxin with emergency department visits for asthma in Kyoto City, Japan. METHODS: We collected data on emergency department visits at a hospital in Kyoto from September 2014 to May 2016. Fine (aerodynamic diameter ≤ 2.5 μm) and coarse (≥ 2.5 μm) particles were collected in Kyoto, and protein and endotoxin levels were analyzed. The association of the levels of particles, protein, endotoxin, and meteorological factors (temperature, relative humidity, wind speed, and air pressure) with emergency department visits for asthma was estimated. RESULTS: There were 1 to 15 emergency department visits for asthma per week, and the numbers of visits increased in the autumn and spring, namely many weeks in September, October, and April. Weekly concentration of protein in fine particles was markedly higher than that in coarse particles, and protein concentration in fine particles was high in spring months. Weekly endotoxin concentrations in fine and coarse particles were high in autumn months, including September 2014 and 2015. Even after adjusting for meteorological factors, the concentrations of coarse particles and endotoxin in both particles were significant factors on emergency department visits for asthma. CONCLUSIONS: Our results suggest that atmospheric coarse particles and endotoxin are significantly associated with an increased risk of asthma exacerbation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12199-018-0731-2) contains supplementary material, which is available to authorized users. BioMed Central 2018-08-28 2018 /pmc/articles/PMC6114267/ /pubmed/30153806 http://dx.doi.org/10.1186/s12199-018-0731-2 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Khan, Mohammad Shahriar Coulibaly, Souleymane Matsumoto, Takahiro Yano, Yoshitaka Miura, Makoto Nagasaka, Yukio Shima, Masayuki Yamagishi, Nobuyuki Wakabayashi, Keiji Watanabe, Tetsushi Association of airborne particles, protein, and endotoxin with emergency department visits for asthma in Kyoto, Japan |
title | Association of airborne particles, protein, and endotoxin with emergency department visits for asthma in Kyoto, Japan |
title_full | Association of airborne particles, protein, and endotoxin with emergency department visits for asthma in Kyoto, Japan |
title_fullStr | Association of airborne particles, protein, and endotoxin with emergency department visits for asthma in Kyoto, Japan |
title_full_unstemmed | Association of airborne particles, protein, and endotoxin with emergency department visits for asthma in Kyoto, Japan |
title_short | Association of airborne particles, protein, and endotoxin with emergency department visits for asthma in Kyoto, Japan |
title_sort | association of airborne particles, protein, and endotoxin with emergency department visits for asthma in kyoto, japan |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114267/ https://www.ncbi.nlm.nih.gov/pubmed/30153806 http://dx.doi.org/10.1186/s12199-018-0731-2 |
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