Prognostic significance of tumor-infiltrating lymphocytes in patients with operable tongue cancer

BACKGROUND: Our aim was to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in operable tongue cancer patients. METHODS: The presence of CD3(+), CD4(+), CD8(+), and forkhead box protein P3-positive (FOXP3(+)) TILs in tumor tissues obtained from 93 patients during surg...

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Detalles Bibliográficos
Autores principales: Chen, Wan-Yu, Wu, Chen-Tu, Wang, Chun-Wei, Lan, Keng-Hsueh, Liang, Hsiang-Kuang, Huang, Bing-Shen, Chang, Yih-Leong, Kuo, Sung-Hsin, Cheng, Ann-Lii
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114480/
https://www.ncbi.nlm.nih.gov/pubmed/30153850
http://dx.doi.org/10.1186/s13014-018-1099-6
Descripción
Sumario:BACKGROUND: Our aim was to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in operable tongue cancer patients. METHODS: The presence of CD3(+), CD4(+), CD8(+), and forkhead box protein P3-positive (FOXP3(+)) TILs in tumor tissues obtained from 93 patients during surgery was examined using immunohistochemistry. RESULTS: The 3-year overall survival (OS) of patients with a low CD8/FOXP3 ratio was significantly lower than that of patients with a high CD8/FOXP3 ratio (63.8% vs. 87.3%, p = 0.001). Patients with high FOXP3 had a significantly lower 3-year regional recurrence-free survival (RRFS) than did patients with low FOXP3 (49.3% vs. 87.3%, univariate log rank p = 0.000). A low CD4/FOXP3 ratio (68.4% vs. 93.7%, univariate log rank p = 0.002) was significantly unfavorable prognostic factors for 3-year distant metastasis-free survival (DMFS). CONCLUSIONS: In addition to clinicopathological characteristics, TIL markers represent prognosticators for clinical outcomes.

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