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Pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature

BACKGROUND: Breast carcinoma with osteoclast-like giant cells (OGCs) is infrequent, being most reported cased described as ductal invasive carcinomas. Invasive pleomorphic lobular carcinoma (PLC) is a distinct morphological variant of invasive lobular carcinoma characterized by higher nuclear atypia...

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Autores principales: Peña-Jaimes, Lourdes, González-García, Irene, Reguero-Callejas, María Eugenia, Pinilla-Pagnon, Ignacio, Pérez-Mies, Belén, Albarrán-Artahona, Víctor, Martínez-Jañez, Noelia, Rosa-Rosa, Juan Manuel, Palacios, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114493/
https://www.ncbi.nlm.nih.gov/pubmed/30153845
http://dx.doi.org/10.1186/s13000-018-0744-6
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author Peña-Jaimes, Lourdes
González-García, Irene
Reguero-Callejas, María Eugenia
Pinilla-Pagnon, Ignacio
Pérez-Mies, Belén
Albarrán-Artahona, Víctor
Martínez-Jañez, Noelia
Rosa-Rosa, Juan Manuel
Palacios, José
author_facet Peña-Jaimes, Lourdes
González-García, Irene
Reguero-Callejas, María Eugenia
Pinilla-Pagnon, Ignacio
Pérez-Mies, Belén
Albarrán-Artahona, Víctor
Martínez-Jañez, Noelia
Rosa-Rosa, Juan Manuel
Palacios, José
author_sort Peña-Jaimes, Lourdes
collection PubMed
description BACKGROUND: Breast carcinoma with osteoclast-like giant cells (OGCs) is infrequent, being most reported cased described as ductal invasive carcinomas. Invasive pleomorphic lobular carcinoma (PLC) is a distinct morphological variant of invasive lobular carcinoma characterized by higher nuclear atypia and pleomorphism than the classical type. In the best of our knowledge, a PLC with OGCs has not been previously reported. CASE PRESENTATION: We report the case of a 72-year-old woman presenting with a pleomorphic tumor of the left breast with a dense infiltration by OGCs and T lymphocytes with a 10:1 predominance of CD8+ over CD4+ cells. The diagnosis of a lymphoid or mesenchymal neoplasia was excluded after demonstrating keratin expression by the neoplastic cells. The absence of E-cadherin expression and the morphological features were consistent with the diagnosis PLC with OGCs. In addition, we demonstrated the deleterious mutation C.del866C in CDH1gene, but no mutations in any of the other 33 genes analyzed by next generation sequencing. CONCLUSIONS: Breast carcinoma with stromal osteoclast-like giant cells is a very rare tumor, for that reason, the use of the cytologic features and growth patterns in combination with immunohistochemically studies is mandatory for a correct diagnosis of lobular carcinoma. In addition, further studies are necessary to clarify the influence of OGCs in the prognosis of these patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13000-018-0744-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-61144932018-09-04 Pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature Peña-Jaimes, Lourdes González-García, Irene Reguero-Callejas, María Eugenia Pinilla-Pagnon, Ignacio Pérez-Mies, Belén Albarrán-Artahona, Víctor Martínez-Jañez, Noelia Rosa-Rosa, Juan Manuel Palacios, José Diagn Pathol Case Report BACKGROUND: Breast carcinoma with osteoclast-like giant cells (OGCs) is infrequent, being most reported cased described as ductal invasive carcinomas. Invasive pleomorphic lobular carcinoma (PLC) is a distinct morphological variant of invasive lobular carcinoma characterized by higher nuclear atypia and pleomorphism than the classical type. In the best of our knowledge, a PLC with OGCs has not been previously reported. CASE PRESENTATION: We report the case of a 72-year-old woman presenting with a pleomorphic tumor of the left breast with a dense infiltration by OGCs and T lymphocytes with a 10:1 predominance of CD8+ over CD4+ cells. The diagnosis of a lymphoid or mesenchymal neoplasia was excluded after demonstrating keratin expression by the neoplastic cells. The absence of E-cadherin expression and the morphological features were consistent with the diagnosis PLC with OGCs. In addition, we demonstrated the deleterious mutation C.del866C in CDH1gene, but no mutations in any of the other 33 genes analyzed by next generation sequencing. CONCLUSIONS: Breast carcinoma with stromal osteoclast-like giant cells is a very rare tumor, for that reason, the use of the cytologic features and growth patterns in combination with immunohistochemically studies is mandatory for a correct diagnosis of lobular carcinoma. In addition, further studies are necessary to clarify the influence of OGCs in the prognosis of these patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13000-018-0744-6) contains supplementary material, which is available to authorized users. BioMed Central 2018-08-28 /pmc/articles/PMC6114493/ /pubmed/30153845 http://dx.doi.org/10.1186/s13000-018-0744-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Peña-Jaimes, Lourdes
González-García, Irene
Reguero-Callejas, María Eugenia
Pinilla-Pagnon, Ignacio
Pérez-Mies, Belén
Albarrán-Artahona, Víctor
Martínez-Jañez, Noelia
Rosa-Rosa, Juan Manuel
Palacios, José
Pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature
title Pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature
title_full Pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature
title_fullStr Pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature
title_full_unstemmed Pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature
title_short Pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature
title_sort pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114493/
https://www.ncbi.nlm.nih.gov/pubmed/30153845
http://dx.doi.org/10.1186/s13000-018-0744-6
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