APP21 transgenic rats develop age-dependent cognitive impairment and microglia accumulation within white matter tracts

BACKGROUND: Most of the animal models commonly used for preclinical research into Alzheimer’s disease (AD) largely fail to address the pathophysiology, including the impact of known risk factors, of the widely diagnosed sporadic form of the disease. Here, we use a transgenic rat (APP21) that does no...

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Detalles Bibliográficos
Autores principales: Weishaupt, Nina, Liu, Qingfan, Shin, Sheojung, Singh, Ramandeep, Agca, Yuksel, Agca, Cansu, Hachinski, Vladimir, Whitehead, Shawn Narain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114740/
https://www.ncbi.nlm.nih.gov/pubmed/30153843
http://dx.doi.org/10.1186/s12974-018-1273-7

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