Cargando…
Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice
Previous studies have shown that modified apelin analogues exhibited enzyme resistance in plasma and improved circulating half-life compared to apelin-13. This study investigated the antidiabetic effects of chronic administration of stable long acting fatty acid modified apelin analogues, namely, (L...
Autores principales: | O’Harte, Finbarr P. M., Parthsarathy, Vadivel, Hogg, Christopher, Flatt, Peter R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114795/ https://www.ncbi.nlm.nih.gov/pubmed/30157220 http://dx.doi.org/10.1371/journal.pone.0202350 |
Ejemplares similares
-
Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update
por: Palmer, Ethan S, et al.
Publicado: (2022) -
Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice
por: Lafferty, Ryan A, et al.
Publicado: (2022) -
An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice
por: Hasib, Annie, et al.
Publicado: (2016) -
Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca(2+)-PPP3/calcineurin-TFEB axis
por: Zummo, Francesco P, et al.
Publicado: (2021) -
Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats
por: Mehri, Keyvan, et al.
Publicado: (2019)