A novel panel of short mononucleotide repeats linked to informative polymorphisms enabling effective high volume low cost discrimination between mismatch repair deficient and proficient tumours

Somatic mutations in mononucleotide repeats are commonly used to assess the mismatch repair status of tumours. Current tests focus on repeats with a length above 15bp, which tend to be somatically more unstable than shorter ones. These longer repeats also have a substantially higher PCR error rate,...

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Detalles Bibliográficos
Autores principales: Redford, Lisa, Alhilal, Ghanim, Needham, Stephanie, O’Brien, Ottie, Coaker, Julie, Tyson, John, Amorim, Leonardo Maldaner, Middleton, Iona, Izuogu, Osagi, Arends, Mark, Oniscu, Anca, Alonso, Ángel Miguel, Laguna, Sira Moreno, Gallon, Richard, Sheth, Harsh, Santibanez-Koref, Mauro, Jackson, Michael S., Burn, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114912/
https://www.ncbi.nlm.nih.gov/pubmed/30157243
http://dx.doi.org/10.1371/journal.pone.0203052

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