Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids

Herein, we describe the first linear-selective hydroarylation reaction of unactivated alkenes and styrenes with aryl boronic acids, which was achieved by introducing a directing group on the alkenes. This efficient, scalable reaction serves as a method for modular assembly of structurally diverse al...

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Detalles Bibliográficos
Autores principales: Lv, Honggui, Xiao, Li-Jun, Zhao, Dongbing, Zhou, Qi-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115005/
https://www.ncbi.nlm.nih.gov/pubmed/30310616
http://dx.doi.org/10.1039/c8sc02101e
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author Lv, Honggui
Xiao, Li-Jun
Zhao, Dongbing
Zhou, Qi-Lin
author_facet Lv, Honggui
Xiao, Li-Jun
Zhao, Dongbing
Zhou, Qi-Lin
author_sort Lv, Honggui
collection PubMed
description Herein, we describe the first linear-selective hydroarylation reaction of unactivated alkenes and styrenes with aryl boronic acids, which was achieved by introducing a directing group on the alkenes. This efficient, scalable reaction serves as a method for modular assembly of structurally diverse alkyl arenes, including γ-aryl butyric acid derivatives, which are widely utilized as chemical building blocks for the synthesis of various drugs and other biologically active compounds.
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spelling pubmed-61150052018-10-11 Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids Lv, Honggui Xiao, Li-Jun Zhao, Dongbing Zhou, Qi-Lin Chem Sci Chemistry Herein, we describe the first linear-selective hydroarylation reaction of unactivated alkenes and styrenes with aryl boronic acids, which was achieved by introducing a directing group on the alkenes. This efficient, scalable reaction serves as a method for modular assembly of structurally diverse alkyl arenes, including γ-aryl butyric acid derivatives, which are widely utilized as chemical building blocks for the synthesis of various drugs and other biologically active compounds. Royal Society of Chemistry 2018-07-18 /pmc/articles/PMC6115005/ /pubmed/30310616 http://dx.doi.org/10.1039/c8sc02101e Text en This journal is © The Royal Society of Chemistry 2018 https://creativecommons.org/licenses/by-nc/3.0/This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Lv, Honggui
Xiao, Li-Jun
Zhao, Dongbing
Zhou, Qi-Lin
Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids
title Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids
title_full Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids
title_fullStr Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids
title_full_unstemmed Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids
title_short Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids
title_sort nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115005/
https://www.ncbi.nlm.nih.gov/pubmed/30310616
http://dx.doi.org/10.1039/c8sc02101e
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AT zhaodongbing nickel0catalyzedlinearselectivehydroarylationofunactivatedalkenesandstyreneswitharylboronicacids
AT zhouqilin nickel0catalyzedlinearselectivehydroarylationofunactivatedalkenesandstyreneswitharylboronicacids

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