Molecular characterization and immune responsive expression of feline MDA5 gene

The retinoic acid-inducible gene-I-like receptor (RLR) family is a group of cytosolic RNA helicase proteins that play an important role in sensing viral RNAs. Melanoma differentiation-associated gene 5 (MDA5), an RLR protein, recognizes viral double-stranded RNA and 5’-triphosphate single-stranded R...

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Autores principales: KOBA, Ryota, SHOJI, Sakurako, YOSHIMURA, Sawami, TOHYA, Yukinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115252/
https://www.ncbi.nlm.nih.gov/pubmed/29973480
http://dx.doi.org/10.1292/jvms.17-0278
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author KOBA, Ryota
SHOJI, Sakurako
YOSHIMURA, Sawami
TOHYA, Yukinobu
author_facet KOBA, Ryota
SHOJI, Sakurako
YOSHIMURA, Sawami
TOHYA, Yukinobu
author_sort KOBA, Ryota
collection PubMed
description The retinoic acid-inducible gene-I-like receptor (RLR) family is a group of cytosolic RNA helicase proteins that play an important role in sensing viral RNAs. Melanoma differentiation-associated gene 5 (MDA5), an RLR protein, recognizes viral double-stranded RNA and 5’-triphosphate single-stranded RNA in the cytoplasm for the expression of type I interferon (IFN). The expression of MDA5 is also induced by type I IFN. In the present study, we determined the complete coding sequence of the feline MDA5 gene, and analyzed its structure. In addition, we examined tissue expression patterns, inducibilities of the feline MDA5 by polyinosinic-polycytidylic acid and type I IFN, and a functional role of feline MDA5 on type I IFN expression.
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spelling pubmed-61152522018-09-24 Molecular characterization and immune responsive expression of feline MDA5 gene KOBA, Ryota SHOJI, Sakurako YOSHIMURA, Sawami TOHYA, Yukinobu J Vet Med Sci Immunology The retinoic acid-inducible gene-I-like receptor (RLR) family is a group of cytosolic RNA helicase proteins that play an important role in sensing viral RNAs. Melanoma differentiation-associated gene 5 (MDA5), an RLR protein, recognizes viral double-stranded RNA and 5’-triphosphate single-stranded RNA in the cytoplasm for the expression of type I interferon (IFN). The expression of MDA5 is also induced by type I IFN. In the present study, we determined the complete coding sequence of the feline MDA5 gene, and analyzed its structure. In addition, we examined tissue expression patterns, inducibilities of the feline MDA5 by polyinosinic-polycytidylic acid and type I IFN, and a functional role of feline MDA5 on type I IFN expression. The Japanese Society of Veterinary Science 2018-07-03 2018-08 /pmc/articles/PMC6115252/ /pubmed/29973480 http://dx.doi.org/10.1292/jvms.17-0278 Text en ©2018 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Immunology
KOBA, Ryota
SHOJI, Sakurako
YOSHIMURA, Sawami
TOHYA, Yukinobu
Molecular characterization and immune responsive expression of feline MDA5 gene
title Molecular characterization and immune responsive expression of feline MDA5 gene
title_full Molecular characterization and immune responsive expression of feline MDA5 gene
title_fullStr Molecular characterization and immune responsive expression of feline MDA5 gene
title_full_unstemmed Molecular characterization and immune responsive expression of feline MDA5 gene
title_short Molecular characterization and immune responsive expression of feline MDA5 gene
title_sort molecular characterization and immune responsive expression of feline mda5 gene
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115252/
https://www.ncbi.nlm.nih.gov/pubmed/29973480
http://dx.doi.org/10.1292/jvms.17-0278
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AT yoshimurasawami molecularcharacterizationandimmuneresponsiveexpressionoffelinemda5gene
AT tohyayukinobu molecularcharacterizationandimmuneresponsiveexpressionoffelinemda5gene

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