Effect of intramammary lipopolysaccharide infusion on milk pH of uninfused udder in goat

The change in milk composition in response to intramammary infusion of Escherichia coli lipopolysaccharide (LPS) was investigated. Four clinically healthy goats were infused with LPS (100 µg) by intramammary administration to the left udder. Clinical manifestations (rectal temperature and physical activity), selected blood parameters (pH and white blood cell count) and milk compositions (somatic cell count and pH) were evaluated at 0 hr (just before challenge) and at multiple time points over the first 24 hr post-challenge. After intramammary LPS challenge, the pH of milk from both udders increased. Thus, this study revealed that LPS-induced mastitis in goat can result in increased pH in milk from the unchallenged (contralateral) udder.