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The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia

Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been associated with neuromodulatory functions yet. T...

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Autores principales: Otto, Nils, Marelja, Zvonimir, Schoofs, Andreas, Kranenburg, Holger, Bittern, Jonas, Yildirim, Kerem, Berh, Dimitri, Bethke, Maria, Thomas, Silke, Rode, Sandra, Risse, Benjamin, Jiang, Xiaoyi, Pankratz, Michael, Leimkühler, Silke, Klämbt, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115356/
https://www.ncbi.nlm.nih.gov/pubmed/30158546
http://dx.doi.org/10.1038/s41467-018-05645-z
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author Otto, Nils
Marelja, Zvonimir
Schoofs, Andreas
Kranenburg, Holger
Bittern, Jonas
Yildirim, Kerem
Berh, Dimitri
Bethke, Maria
Thomas, Silke
Rode, Sandra
Risse, Benjamin
Jiang, Xiaoyi
Pankratz, Michael
Leimkühler, Silke
Klämbt, Christian
author_facet Otto, Nils
Marelja, Zvonimir
Schoofs, Andreas
Kranenburg, Holger
Bittern, Jonas
Yildirim, Kerem
Berh, Dimitri
Bethke, Maria
Thomas, Silke
Rode, Sandra
Risse, Benjamin
Jiang, Xiaoyi
Pankratz, Michael
Leimkühler, Silke
Klämbt, Christian
author_sort Otto, Nils
collection PubMed
description Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been associated with neuromodulatory functions yet. To decipher a possible role of ensheathing glia in neuronal information processing, we screened for glial genes required in the Drosophila central nervous system for normal locomotor behavior. Shopper encodes a mitochondrial sulfite oxidase that is specifically required in ensheathing glia to regulate head bending and peristalsis. shopper mutants show elevated sulfite levels affecting the glutamate homeostasis which then act on neuronal network function. Interestingly, human patients lacking the Shopper homolog SUOX develop neurological symptoms, including seizures. Given an enhanced expression of SUOX by oligodendrocytes, our findings might indicate that in both invertebrates and vertebrates more than one glial cell type may be involved in modulating neuronal activity.
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spelling pubmed-61153562018-08-31 The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia Otto, Nils Marelja, Zvonimir Schoofs, Andreas Kranenburg, Holger Bittern, Jonas Yildirim, Kerem Berh, Dimitri Bethke, Maria Thomas, Silke Rode, Sandra Risse, Benjamin Jiang, Xiaoyi Pankratz, Michael Leimkühler, Silke Klämbt, Christian Nat Commun Article Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been associated with neuromodulatory functions yet. To decipher a possible role of ensheathing glia in neuronal information processing, we screened for glial genes required in the Drosophila central nervous system for normal locomotor behavior. Shopper encodes a mitochondrial sulfite oxidase that is specifically required in ensheathing glia to regulate head bending and peristalsis. shopper mutants show elevated sulfite levels affecting the glutamate homeostasis which then act on neuronal network function. Interestingly, human patients lacking the Shopper homolog SUOX develop neurological symptoms, including seizures. Given an enhanced expression of SUOX by oligodendrocytes, our findings might indicate that in both invertebrates and vertebrates more than one glial cell type may be involved in modulating neuronal activity. Nature Publishing Group UK 2018-08-29 /pmc/articles/PMC6115356/ /pubmed/30158546 http://dx.doi.org/10.1038/s41467-018-05645-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Otto, Nils
Marelja, Zvonimir
Schoofs, Andreas
Kranenburg, Holger
Bittern, Jonas
Yildirim, Kerem
Berh, Dimitri
Bethke, Maria
Thomas, Silke
Rode, Sandra
Risse, Benjamin
Jiang, Xiaoyi
Pankratz, Michael
Leimkühler, Silke
Klämbt, Christian
The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia
title The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia
title_full The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia
title_fullStr The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia
title_full_unstemmed The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia
title_short The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia
title_sort sulfite oxidase shopper controls neuronal activity by regulating glutamate homeostasis in drosophila ensheathing glia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115356/
https://www.ncbi.nlm.nih.gov/pubmed/30158546
http://dx.doi.org/10.1038/s41467-018-05645-z
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