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The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia
Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been associated with neuromodulatory functions yet. T...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115356/ https://www.ncbi.nlm.nih.gov/pubmed/30158546 http://dx.doi.org/10.1038/s41467-018-05645-z |
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author | Otto, Nils Marelja, Zvonimir Schoofs, Andreas Kranenburg, Holger Bittern, Jonas Yildirim, Kerem Berh, Dimitri Bethke, Maria Thomas, Silke Rode, Sandra Risse, Benjamin Jiang, Xiaoyi Pankratz, Michael Leimkühler, Silke Klämbt, Christian |
author_facet | Otto, Nils Marelja, Zvonimir Schoofs, Andreas Kranenburg, Holger Bittern, Jonas Yildirim, Kerem Berh, Dimitri Bethke, Maria Thomas, Silke Rode, Sandra Risse, Benjamin Jiang, Xiaoyi Pankratz, Michael Leimkühler, Silke Klämbt, Christian |
author_sort | Otto, Nils |
collection | PubMed |
description | Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been associated with neuromodulatory functions yet. To decipher a possible role of ensheathing glia in neuronal information processing, we screened for glial genes required in the Drosophila central nervous system for normal locomotor behavior. Shopper encodes a mitochondrial sulfite oxidase that is specifically required in ensheathing glia to regulate head bending and peristalsis. shopper mutants show elevated sulfite levels affecting the glutamate homeostasis which then act on neuronal network function. Interestingly, human patients lacking the Shopper homolog SUOX develop neurological symptoms, including seizures. Given an enhanced expression of SUOX by oligodendrocytes, our findings might indicate that in both invertebrates and vertebrates more than one glial cell type may be involved in modulating neuronal activity. |
format | Online Article Text |
id | pubmed-6115356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61153562018-08-31 The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia Otto, Nils Marelja, Zvonimir Schoofs, Andreas Kranenburg, Holger Bittern, Jonas Yildirim, Kerem Berh, Dimitri Bethke, Maria Thomas, Silke Rode, Sandra Risse, Benjamin Jiang, Xiaoyi Pankratz, Michael Leimkühler, Silke Klämbt, Christian Nat Commun Article Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been associated with neuromodulatory functions yet. To decipher a possible role of ensheathing glia in neuronal information processing, we screened for glial genes required in the Drosophila central nervous system for normal locomotor behavior. Shopper encodes a mitochondrial sulfite oxidase that is specifically required in ensheathing glia to regulate head bending and peristalsis. shopper mutants show elevated sulfite levels affecting the glutamate homeostasis which then act on neuronal network function. Interestingly, human patients lacking the Shopper homolog SUOX develop neurological symptoms, including seizures. Given an enhanced expression of SUOX by oligodendrocytes, our findings might indicate that in both invertebrates and vertebrates more than one glial cell type may be involved in modulating neuronal activity. Nature Publishing Group UK 2018-08-29 /pmc/articles/PMC6115356/ /pubmed/30158546 http://dx.doi.org/10.1038/s41467-018-05645-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Otto, Nils Marelja, Zvonimir Schoofs, Andreas Kranenburg, Holger Bittern, Jonas Yildirim, Kerem Berh, Dimitri Bethke, Maria Thomas, Silke Rode, Sandra Risse, Benjamin Jiang, Xiaoyi Pankratz, Michael Leimkühler, Silke Klämbt, Christian The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia |
title | The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia |
title_full | The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia |
title_fullStr | The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia |
title_full_unstemmed | The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia |
title_short | The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia |
title_sort | sulfite oxidase shopper controls neuronal activity by regulating glutamate homeostasis in drosophila ensheathing glia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115356/ https://www.ncbi.nlm.nih.gov/pubmed/30158546 http://dx.doi.org/10.1038/s41467-018-05645-z |
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