Cargando…

An adjustment in BMP4 function represents a treatment for diabetic nephropathy and podocyte injury

Podocyte injury has been proposed to play an important role in diabetic nephropathy; however, its pathological mechanism remains unclear. We have shown that bone morphogenetic protein 4 (BMP4) signaling leads to the glomerular changes characteristic of this disorder. To analyze the molecular mechani...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fujita, Yui, Tominaga, Tatsuya, Abe, Hideharu, Kangawa, Yumi, Fukushima, Naoshi, Ueda, Otoya, Jishage, Kou-ichi, Kishi, Seiji, Murakami, Taichi, Saga, Yumiko, Kanwar, Yashpal S., Nagai, Kojiro, Doi, Toshio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115362/ https://www.ncbi.nlm.nih.gov/pubmed/30158674 http://dx.doi.org/10.1038/s41598-018-31464-9

Ejemplares similares

Involvement of Elf3 on Smad3 activation-dependent injuries in podocytes and excretion of urinary exosome in diabetic nephropathy
por: Sakurai, Akiko, et al.
Publicado: (2019)

Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy
por: Ono, Hiroyuki, et al.
Publicado: (2018)

Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes: A 5-year observational study
por: Kishi, Fumi, et al.
Publicado: (2018)

Dual Involvement of Growth Arrest-Specific Gene 6 in the Early Phase of Human IgA Nephropathy
por: Nagai, Kojiro, et al.
Publicado: (2013)

Lambda Light Chain Non-crystalline Proximal Tubulopathy with IgD Lambda Myeloma
por: Kishi, Seiji, et al.
Publicado: (2018)

IgA Nephropathy after Nivolumab Therapy for Postoperative Recurrence of Lung Squamous Cell Carcinoma
por: Kishi, Seiji, et al.
Publicado: (2017)

Circulating Apolipoprotein L1 is associated with insulin resistance-induced abnormal lipid metabolism
por: Nishimura, Kenji, et al.
Publicado: (2019)

Author Correction: Circulating Apolipoprotein L1 is associated with insulin resistance-induced abnormal lipid metabolism
por: Nishimura, Kenji, et al.
Publicado: (2019)

Shunt Nephritis and Pyogenic Spondylitis With a Positive PR3-ANCA Associated With Chronically Infected Ventriculoatrial Shunt
por: Ono, Hiroyuki, et al.
Publicado: (2017)

A Novel Interaction between FLICE-Associated Huge Protein (FLASH) and E2A Regulates Cell Proliferation and Cellular Senescence via Tumor Necrosis Factor (TNF)-Alpha-p21WAF1/CIP1 Axis
por: Hirano, Takahiro, et al.
Publicado: (2015)

TNF-α induces Claudin-1 expression in renal tubules in Alport mice
por: Iida, Manami, et al.
Publicado: (2022)

Systemic Sarcoidosis Presenting with Renal Involvement Caused by Various Sarcoidosis-associated Pathophysiological Conditions
por: Ueda, Sayo, et al.
Publicado: (2018)

Successful treatment of highly advanced immunoglobulin G4-related kidney disease presenting renal mass-like regions with end-stage kidney failure: a case study
por: Ono, Hiroyuki, et al.
Publicado: (2017)

Successful management of refractory pleural effusion due to systemic immunoglobulin light chain amyloidosis by vincristine adriamycin dexamethasone chemotherapy: a case report
por: Araoka, Toshikazu, et al.
Publicado: (2010)

SGLT5 Reabsorbs Fructose in the Kidney but Its Deficiency Paradoxically Exacerbates Hepatic Steatosis Induced by Fructose
por: Fukuzawa, Taku, et al.
Publicado: (2013)

Clinical evaluation of presepsin considering renal function
por: Miyoshi, Masashi, et al.
Publicado: (2019)

Re-recognition of Age-dependent Reference Range for the Serum Creatinine Level in Teenagers - A Case of Slowly Progressive Tubulointerstitial Nephritis which Occurred in an Adolescent -
por: Ono, Hiroyuki, et al.
Publicado: (2017)

Progressive renal insufficiency related to ALK inhibitor, alectinib
por: Nagai, Kojiro, et al.
Publicado: (2018)

Glucocorticoid-dependent Tubulointerstitial Nephritis with IgM-positive Plasma Cells Presenting with Intracellular Crystalline Inclusions within the Rough Endoplasmic Reticulum
por: Minato, Masanori, et al.
Publicado: (2021)

Twisted Gastrulation, a BMP Antagonist, Exacerbates Podocyte Injury
por: Yamada, Sachiko, et al.
Publicado: (2014)

Activation of Src Mediates PDGF-Induced Smad1 Phosphorylation and Contributes to the Progression of Glomerulosclerosis in Glomerulonephritis
por: Mima, Akira, et al.
Publicado: (2011)

Correction: Activation of Src Mediates PDGF-Induced Smad1 Phosphorylation and Contributes to the Progression of Glomerulosclerosis in Glomerulonephritis
por: Mima, Akira, et al.
Publicado: (2012)

Insights into the Regulation of GFR by the Keap1-Nrf2 Pathway
por: Kidokoro, Kengo, et al.
Publicado: (2023)

Risk factors for chronic kidney disease in Japan: a community-based study
por: Takamatsu, Norimichi, et al.
Publicado: (2009)

A case of traumatic intracranial vertebral artery injury presenting with life-threatening symptoms
por: Kishi, Seiji, et al.
Publicado: (2012)

The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing
por: Kim, Jessica, et al.
Publicado: (2022)

Bone morphogenetic protein-3b (BMP-3b) is expressed in adipocytes and inhibits adipogenesis as a unique complex
por: Hino, J, et al.
Publicado: (2012)

Novel genetically-humanized mouse model established to evaluate efficacy of therapeutic agents to human interleukin-6 receptor
por: Ueda, Otoya, et al.
Publicado: (2013)

An Autopsy Case of Aortic Intimal Sarcoma Initially Diagnosed as Polyarteritis Nodosa
por: Toyoda, Yuko, et al.
Publicado: (2016)

RELEVANCE OF TNF-α IN THE CONTEXT OF OTHER INFLAMMATORY CYTOKINES IN THE PROGRESSION OF DIABETIC NEPHROPATHY
por: Sun, Lin, et al.
Publicado: (2015)

Podocytes
por: Reiser, Jochen, et al.
Publicado: (2016)

Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression
por: Kawai, Mariko, et al.
Publicado: (2006)

Endothelin and the podocyte
por: Barton, Matthias, et al.
Publicado: (2012)

Modulation of Renal Injury by Variable Expression of Myo-Inositol Oxygenase (MIOX) via Perturbation in Metabolic Sensors
por: Sharma, Isha, et al.
Publicado: (2020)

Small-Molecule-Mediated Suppression of BMP Signaling by Selective Inhibition of BMP1-Dependent Chordin Cleavage
por: Mizoguchi, Takamasa, et al.
Publicado: (2023)

Semaphorin3A-Inhibitor Ameliorates Doxorubicin-Induced Podocyte Injury
por: Sang, Yizhen, et al.
Publicado: (2020)

A Case of Podocytic Infolding Glomerulopathy with Focal Segmental Glomerulosclerosis
por: Iguchi, Akira, et al.
Publicado: (2013)

Mechanisms and consequences of TGF-ß overexpression by podocytes in progressive podocyte disease
por: Lee, Hyun Soon
Publicado: (2011)

Mosaicism of Podocyte Involvement Is Related to Podocyte Injury in Females with Fabry Disease
por: Mauer, Michael, et al.
Publicado: (2014)

Male advantage observed for in vitro fertilization mouse embryos exhibiting early cleavage
por: Kawase, Yosuke, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r3kibe82gr8vlggmj3gsafiqbj