Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer

Many stress conditions including chemotherapy treatment is known to activate Src and under certain condition Src can induce the apoptotic signal via c-Jun N-terminal kinase (JNK) activation. Here we report that the newly synthesized β-phenylacrylic acid derivatives, MHY791 and MHY1036 (MHYs), bind t...

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Detalles Bibliográficos
Autores principales: Kim, Su Jin, Noh, Tae Hwan, Son, Sujin, Kim, Do Hyun, Kim, Wooseong, Lee, Yunna, Choo, Jieun, Heo, Gwangbeom, Kim, Min Jae, Chung, Hae Young, Jung, Yunjin, Jung, Jee Hyung, Moon, Hyung Ryong, Im, Eunok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115383/
https://www.ncbi.nlm.nih.gov/pubmed/30158525
http://dx.doi.org/10.1038/s41419-018-0942-x

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