Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling

Autophagy impairment is commonly implicated in the pathological characteristic of Alzheimer’s disease (AD). Presenilin 1 (PS1) expression in human brain gradually decreases with age and its mutations account for the most common cases of early-onset familial Alzheimer’s disease (FAD). The dominant au...

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Detalles Bibliográficos
Autores principales: Chong, Cheong-Meng, Ke, Minjing, Tan, Yuan, Huang, Zhijian, Zhang, Ke, Ai, Nana, Ge, Wei, Qin, Dajiang, Lu, Jia-Hong, Su, Huanxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115391/
https://www.ncbi.nlm.nih.gov/pubmed/30158533
http://dx.doi.org/10.1038/s41419-018-0945-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115391/
https://www.ncbi.nlm.nih.gov/pubmed/30158533
http://dx.doi.org/10.1038/s41419-018-0945-7

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