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RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD

Necroptosis predominates functionally over apoptosis in the pathophysiology of renal ischemia-reperfusion injury (IRI). Inhibition of the core components of the necroptotic pathway—receptor-interacting protein kinase 1 (RIPK1), RIPK3 or mixed lineage kinase domain-like protein (MLKL) reduced renal i...

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Detalles Bibliográficos
Autores principales:	Chen, Hui, Fang, Yulu, Wu, Jianfeng, Chen, Hong, Zou, Zhenhuan, Zhang, Xiaohong, Shao, Jing, Xu, Yanfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115414/ https://www.ncbi.nlm.nih.gov/pubmed/30158627 http://dx.doi.org/10.1038/s41419-018-0936-8

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