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Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke
CDK5 activation promotes ischemic neuronal death in stroke, with the recognized activation mechanism being calpain-dependent p35 cleavage to p25. Here we reported that CDK5-Tyr15 phosphorylation by zinc induced CDK5 activation in brain ischemic injury. CDK5 activation and CDK5-Tyr15 phosphorylation...
Autores principales: | Tuo, Qing-Zhang, Liuyang, Zhen-Yu, Lei, Peng, Yan, Xiong, Shentu, Yang-Ping, Liang, Jia-Wei, Zhou, Huan, Pei, Lei, Xiong, Yan, Hou, Tong-Yao, Zhou, Xin-Wen, Wang, Qun, Wang, Jian-Zhi, Wang, Xiao-Chuan, Liu, Rong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115431/ https://www.ncbi.nlm.nih.gov/pubmed/30158515 http://dx.doi.org/10.1038/s41419-018-0929-7 |
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