Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2 also affects cytosolic nucleic acid sensing is currently unknown. Here we identify Nrf2 as an important negative regulator of STING and suggest a link between metabolic reprogramming and antiviral cytoso...

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Detalles Bibliográficos
Autores principales: Olagnier, David, Brandtoft, Aske M., Gunderstofte, Camilla, Villadsen, Nikolaj L., Krapp, Christian, Thielke, Anne L., Laustsen, Anders, Peri, Suraj, Hansen, Anne Louise, Bonefeld, Lene, Thyrsted, Jacob, Bruun, Victor, Iversen, Marie B., Lin, Lin, Artegoitia, Virginia M., Su, Chenhe, Yang, Long, Lin, Rongtuan, Balachandran, Siddharth, Luo, Yonglun, Nyegaard, Mette, Marrero, Bernadette, Goldbach-Mansky, Raphaela, Motwani, Mona, Ryan, Dylan G., Fitzgerald, Katherine A., O’Neill, Luke A., Hollensen, Anne K., Damgaard, Christian K., de Paoli, Frank v., Bertram, Hanne C., Jakobsen, Martin R., Poulsen, Thomas B., Holm, Christian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115435/
https://www.ncbi.nlm.nih.gov/pubmed/30158636
http://dx.doi.org/10.1038/s41467-018-05861-7

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