Release of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosis

Toll-like receptor 3 (TLR3) mediates innate immune responses by sensing viral dsRNA, but also induces apoptosis selectively in cancer cells. Our analysis by immunohistochemistry revealed that TLR3 is frequently overexpressed in 130 non-small cell lung cancer (NSCLC) patients’ samples compared with n...

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Detalles Bibliográficos
Autores principales: Alkurdi, Lugain, Virard, François, Vanbervliet, Béatrice, Weber, Kathrin, Toscano, Florent, Bonnin, Marc, Le Stang, Nolwenn, Lantuejoul, Sylvie, Micheau, Olivier, Renno, Toufic, Lebecque, Serge, Estornes, Yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115461/
https://www.ncbi.nlm.nih.gov/pubmed/30158588
http://dx.doi.org/10.1038/s41419-018-0850-0

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